Megens AA - Search Results

1

Risperidone and related 5HT2/D2 antagonists: a new type of antipsychotic agent?

Megens AA, Kennis LE. Megens AA, et al. Prog Med Chem. 1996;33:185-232. doi: 10.1016/s0079-6468(08)70306-0. Prog Med Chem. 1996. PMID: 8776944 Review. No abstract available.

2

New 2-substituted 1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine having highly active and potent central alpha 2-antagonistic activity as potential antidepressants.

Kennis LE, Bischoff FP, Mertens CJ, Love CJ, Van den Keybus FA, Pieters S, Braeken M, Megens AA, Leysen JE. Kennis LE, et al. Among authors: megens aa. Bioorg Med Chem Lett. 2000 Jan 3;10(1):71-4. doi: 10.1016/s0960-894x(99)00591-0. Bioorg Med Chem Lett. 2000. PMID: 10636247

3

Preclinical assessment of the feasibility of applying controlled release oral drug delivery to a lead series of atypical antipsychotics.

Eichenbaum G, Pollock-Dove C, Nguyen J, Li S, Evans J, Borghys H, Kennis L, Dong L, van Osdol W, Dai W, Scicinski J, Chen J, Xu Y, Ashton D, Mackie C, Megens A. Eichenbaum G, et al. J Pharm Sci. 2006 Apr;95(4):883-95. doi: 10.1002/jps.20550. J Pharm Sci. 2006. PMID: 16489607

4

Survey on the pharmacodynamics of the new antipsychotic risperidone.

Megens AA, Awouters FH, Schotte A, Meert TF, Dugovic C, Niemegeers CJ, Leysen JE. Megens AA, et al. Psychopharmacology (Berl). 1994 Feb;114(1):9-23. doi: 10.1007/BF02245439. Psychopharmacology (Berl). 1994. PMID: 7531353 Review.

5

Norpiperidine imidazoazepines as a new class of potent, selective, and nonsedative H1 antihistamines.

Janssens F, Leenaerts J, Diels G, De Boeck B, Megens A, Langlois X, van Rossem K, Beetens J, Borgers M. Janssens F, et al. J Med Chem. 2005 Mar 24;48(6):2154-66. doi: 10.1021/jm049495j. J Med Chem. 2005. PMID: 15771458

6

Pharmacology of risperidone (R 64 766), a new antipsychotic with serotonin-S2 and dopamine-D2 antagonistic properties.

Janssen PA, Niemegeers CJ, Awouters F, Schellekens KH, Megens AA, Meert TF. Janssen PA, et al. Among authors: megens aa. J Pharmacol Exp Ther. 1988 Feb;244(2):685-93. J Pharmacol Exp Ther. 1988. PMID: 2450200

7

Discovery of a potent, selective, and orally active phosphodiesterase 10A inhibitor for the potential treatment of schizophrenia.

Bartolomé-Nebreda JM, Delgado F, Martín-Martín ML, Martínez-Viturro CM, Pastor J, Tong HM, Iturrino L, Macdonald GJ, Sanderson W, Megens A, Langlois X, Somers M, Vanhoof G, Conde-Ceide S. Bartolomé-Nebreda JM, et al. J Med Chem. 2014 May 22;57(10):4196-212. doi: 10.1021/jm500073h. Epub 2014 May 9. J Med Chem. 2014. PMID: 24758746

8

Identification of a novel orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor with efficacy in animal models of schizophrenia.

Bartolomé-Nebreda JM, Alonso de Diego SA, Artola M, Delgado F, Delgado Ó, Martín-Martín ML, Martínez-Viturro CM, Pena MÁ, Tong HM, Van Gool M, Alonso JM, Fontana A, Macdonald GJ, Megens A, Langlois X, Somers M, Vanhoof G, Conde-Ceide S. Bartolomé-Nebreda JM, et al. J Med Chem. 2015 Jan 22;58(2):978-93. doi: 10.1021/jm501651a. Epub 2015 Jan 12. J Med Chem. 2015. PMID: 25495129

9

Differential effects of the new antipsychotic risperidone on large and small motor movements in rats: a comparison with haloperidol.

Megens AA, Awouters FH, Niemegeers CJ. Megens AA, et al. Psychopharmacology (Berl). 1988;95(4):493-6. doi: 10.1007/BF00172961. Psychopharmacology (Berl). 1988. PMID: 2463650

10

Interaction of antipsychotic drugs with neurotransmitter receptor sites in vitro and in vivo in relation to pharmacological and clinical effects: role of 5HT2 receptors.

Leysen JE, Janssen PM, Schotte A, Luyten WH, Megens AA. Leysen JE, et al. Among authors: megens aa. Psychopharmacology (Berl). 1993;112(1 Suppl):S40-54. doi: 10.1007/BF02245006. Psychopharmacology (Berl). 1993. PMID: 7530377

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