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The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling.
Huang HS, Nagane M, Klingbeil CK, Lin H, Nishikawa R, Ji XD, Huang CM, Gill GN, Wiley HS, Cavenee WK. Huang HS, et al. Among authors: huang cm. J Biol Chem. 1997 Jan 31;272(5):2927-35. doi: 10.1074/jbc.272.5.2927. J Biol Chem. 1997. PMID: 9006938 Free article.
599 results