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Functional interplay of p53 and Mus81 in DNA damage responses and cancer.
Pamidi A, Cardoso R, Hakem A, Matysiak-Zablocki E, Poonepalli A, Tamblyn L, Perez-Ordonez B, Hande MP, Sanchez O, Hakem R. Pamidi A, et al. Among authors: hakem a, hakem r. Cancer Res. 2007 Sep 15;67(18):8527-35. doi: 10.1158/0008-5472.CAN-07-1161. Cancer Res. 2007. PMID: 17875692
Collaboration of Brca1 and Chk2 in tumorigenesis.
McPherson JP, Lemmers B, Hirao A, Hakem A, Abraham J, Migon E, Matysiak-Zablocki E, Tamblyn L, Sanchez-Sweatman O, Khokha R, Squire J, Hande MP, Mak TW, Hakem R. McPherson JP, et al. Among authors: hakem a, hakem r. Genes Dev. 2004 May 15;18(10):1144-53. doi: 10.1101/gad.1192704. Epub 2004 May 6. Genes Dev. 2004. PMID: 15131084 Free PMC article.
Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity.
McPherson JP, Tamblyn L, Elia A, Migon E, Shehabeldin A, Matysiak-Zablocki E, Lemmers B, Salmena L, Hakem A, Fish J, Kassam F, Squire J, Bruneau BG, Hande MP, Hakem R. McPherson JP, et al. Among authors: hakem a, hakem r. EMBO J. 2004 Sep 15;23(18):3677-88. doi: 10.1038/sj.emboj.7600371. Epub 2004 Sep 2. EMBO J. 2004. PMID: 15343267 Free PMC article.
A role for Brca1 in chromosome end maintenance.
McPherson JP, Hande MP, Poonepalli A, Lemmers B, Zablocki E, Migon E, Shehabeldin A, Porras A, Karaskova J, Vukovic B, Squire J, Hakem R. McPherson JP, et al. Among authors: hakem r. Hum Mol Genet. 2006 Mar 15;15(6):831-8. doi: 10.1093/hmg/ddl002. Epub 2006 Jan 30. Hum Mol Genet. 2006. PMID: 16446310
Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer.
El Ghamrasni S, Pamidi A, Halaby MJ, Bohgaki M, Cardoso R, Li L, Venkatesan S, Sethu S, Hirao A, Mak TW, Hande MP, Hakem A, Hakem R. El Ghamrasni S, et al. Among authors: hakem a, hakem r. PLoS Genet. 2011 May;7(5):e1001385. doi: 10.1371/journal.pgen.1001385. Epub 2011 May 19. PLoS Genet. 2011. PMID: 21625617 Free PMC article.
116 results