Martin J - Search Results

1

Gene-directed enzyme prodrug therapy with a mustard prodrug/carboxypeptidase G2 combination.

Marais R, Spooner RA, Light Y, Martin J, Springer CJ. Marais R, et al. Among authors: martin j. Cancer Res. 1996 Oct 15;56(20):4735-42. Cancer Res. 1996. PMID: 8840992

2

Self-immolative nitrogen mustards prodrugs cleavable by carboxypeptidase G2 (CPG2) showing large cytotoxicity differentials in GDEPT.

Niculescu-Duvaz D, Niculescu-Duvaz I, Friedlos F, Martin J, Lehouritis P, Marais R, Springer CJ. Niculescu-Duvaz D, et al. Among authors: martin j. J Med Chem. 2003 Apr 24;46(9):1690-705. doi: 10.1021/jm020462i. J Med Chem. 2003. PMID: 12699387

3

Novel fluorinated prodrugs for activation by carboxypeptidase G2 showing good in vivo antitumor activity in gene-directed enzyme prodrug therapy.

Davies LC, Friedlos F, Hedley D, Martin J, Ogilvie LM, Scanlon IJ, Springer CJ. Davies LC, et al. Among authors: martin j. J Med Chem. 2005 Aug 11;48(16):5321-8. doi: 10.1021/jm0502182. J Med Chem. 2005. PMID: 16078849

4

Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy.

Friedlos F, Lehouritis P, Ogilvie L, Hedley D, Davies L, Bermudes D, King I, Martin J, Marais R, Springer CJ. Friedlos F, et al. Among authors: martin j. Clin Cancer Res. 2008 Jul 1;14(13):4259-66. doi: 10.1158/1078-0432.CCR-07-4800. Clin Cancer Res. 2008. PMID: 18594008

5

Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models.

Friedlos F, Davies L, Scanlon I, Ogilvie LM, Martin J, Stribbling SM, Spooner RA, Niculescu-Duvaz I, Marais R, Springer CJ. Friedlos F, et al. Among authors: martin j. Cancer Res. 2002 Mar 15;62(6):1724-9. Cancer Res. 2002. PMID: 11912146

6

Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2.

Schepelmann S, Hallenbeck P, Ogilvie LM, Hedley D, Friedlos F, Martin J, Scanlon I, Hay C, Hawkins LK, Marais R, Springer CJ. Schepelmann S, et al. Among authors: martin j. Cancer Res. 2005 Jun 15;65(12):5003-8. doi: 10.1158/0008-5472.CAN-05-0393. Cancer Res. 2005. PMID: 15958540

7

Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2.

Schepelmann S, Ogilvie LM, Hedley D, Friedlos F, Martin J, Scanlon I, Chen P, Marais R, Springer CJ. Schepelmann S, et al. Among authors: martin j. Cancer Res. 2007 May 15;67(10):4949-55. doi: 10.1158/0008-5472.CAN-07-0297. Cancer Res. 2007. PMID: 17510425 Free article.

8

Antibody-directed enzyme prodrug therapy: pharmacokinetics and plasma levels of prodrug and drug in a phase I clinical trial.

Martin J, Stribbling SM, Poon GK, Begent RH, Napier M, Sharma SK, Springer CJ. Martin J, et al. Cancer Chemother Pharmacol. 1997;40(3):189-201. doi: 10.1007/s002800050646. Cancer Chemother Pharmacol. 1997. PMID: 9219501 Clinical Trial.

9

Biodistribution of an antibody-enzyme conjugate for antibody-directed enzyme prodrug therapy in nude mice bearing a human colon adenocarcinoma xenograft.

Stribbling SM, Martin J, Pedley RB, Boden JA, Sharma SK, Springer CJ. Stribbling SM, et al. Among authors: martin j. Cancer Chemother Pharmacol. 1997;40(4):277-84. doi: 10.1007/s002800050659. Cancer Chemother Pharmacol. 1997. PMID: 9225945

10

A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy.

Marais R, Spooner RA, Stribbling SM, Light Y, Martin J, Springer CJ. Marais R, et al. Among authors: martin j. Nat Biotechnol. 1997 Dec;15(13):1373-7. doi: 10.1038/nbt1297-1373. Nat Biotechnol. 1997. PMID: 9415889

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