Wetzel R - Search Results

1

A paradigm for drug discovery using a conformation from the crystal structure of a presentation scaffold.

Zhao B, Helms LR, DesJarlais RL, Abdel-Meguid SS, Wetzel R. Zhao B, et al. Among authors: wetzel r. Nat Struct Biol. 1995 Dec;2(12):1131-7. doi: 10.1038/nsb1295-1131. Nat Struct Biol. 1995. PMID: 8846226

2

Strong inhibition of fibrinogen binding to platelet receptor alpha IIb beta 3 by RGD sequences installed into a presentation scaffold.

Lee G, Chan W, Hurle MR, DesJarlais RL, Watson F, Sathe GM, Wetzel R. Lee G, et al. Among authors: wetzel r. Protein Eng. 1993 Sep;6(7):745-54. doi: 10.1093/protein/6.7.745. Protein Eng. 1993. PMID: 8248098

3

Destabilizing loop swaps in the CDRs of an immunoglobulin VL domain.

Helms LR, Wetzel R. Helms LR, et al. Among authors: wetzel r. Protein Sci. 1995 Oct;4(10):2073-81. doi: 10.1002/pro.5560041012. Protein Sci. 1995. PMID: 8535243 Free PMC article.

4

Proteolytic excision and in situ cyclization of a bioactive loop from an REI-VL presentation scaffold.

Helms LR, Wetzel R. Helms LR, et al. Among authors: wetzel r. Protein Sci. 1994 Jul;3(7):1108-13. doi: 10.1002/pro.5560030714. Protein Sci. 1994. PMID: 7920257 Free PMC article.

Previously we described a 2-step procedure for cyclizing purified, native peptides in aqueous solution by reacting a Met or Lys side chain with an iodoacetylated N-terminus (Wood SJ, Wetzel R, 1992a, Int J Pept Protein Res 39:533-539). We show here that the cyclizat …

Previously we described a 2-step procedure for cyclizing purified, native peptides in aqueous solution by reacting a Met or Lys side chain w …

5

Specificity of abnormal assembly in immunoglobulin light chain deposition disease and amyloidosis.

Helms LR, Wetzel R. Helms LR, et al. Among authors: wetzel r. J Mol Biol. 1996 Mar 22;257(1):77-86. doi: 10.1006/jmbi.1996.0148. J Mol Biol. 1996. PMID: 8632461

6

Mutational effects on inclusion body formation in the periplasmic expression of the immunoglobulin VL domain REI.

Chan W, Helms LR, Brooks I, Lee G, Ngola S, McNulty D, Maleeff B, Hensley P, Wetzel R. Chan W, et al. Among authors: wetzel r. Fold Des. 1996;1(2):77-89. doi: 10.1016/s1359-0278(96)00017-x. Fold Des. 1996. PMID: 9079368

7

A role for destabilizing amino acid replacements in light-chain amyloidosis.

Hurle MR, Helms LR, Li L, Chan W, Wetzel R. Hurle MR, et al. Among authors: wetzel r. Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5446-50. doi: 10.1073/pnas.91.12.5446. Proc Natl Acad Sci U S A. 1994. PMID: 8202506 Free PMC article.

8

Prolines and amyloidogenicity in fragments of the Alzheimer's peptide beta/A4.

Wood SJ, Wetzel R, Martin JD, Hurle MR. Wood SJ, et al. Among authors: wetzel r. Biochemistry. 1995 Jan 24;34(3):724-30. doi: 10.1021/bi00003a003. Biochemistry. 1995. PMID: 7827029

9

Inclusion body formation by interleukin-1 beta depends on the thermal sensitivity of a folding intermediate.

Wetzel R, Chrunyk BA. Wetzel R, et al. FEBS Lett. 1994 Aug 22;350(2-3):245-8. doi: 10.1016/0014-5793(94)00775-6. FEBS Lett. 1994. PMID: 8070572 Free article.

10

Selective inhibition of Abeta fibril formation.

Wood SJ, MacKenzie L, Maleeff B, Hurle MR, Wetzel R. Wood SJ, et al. Among authors: wetzel r. J Biol Chem. 1996 Feb 23;271(8):4086-92. doi: 10.1074/jbc.271.8.4086. J Biol Chem. 1996. PMID: 8626745 Free article.

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