Greenberger LM - Search Results

1

alpha-(3,4-dimethyoxyphenyl)-3,4-dihydro-6,7-dimethoxy-alpha- [(4-methylphenyl)thio]-2(1H)-isoquinolineheptanenitrile (CL 329,753): a novel chemosensitizing agent for P-glycoprotein-mediated resistance with improved biological properties compared with verapamil and cyclosporine A.

Greenberger LM, Collins KI, Annable T, Boni JP, May MK, Lai FM, Kramer R, Citeralla RV, Hallett WA, Powell D. Greenberger LM, et al. Oncol Res. 1996;8(5):207-18. Oncol Res. 1996. PMID: 8884813

2

P-glycoprotein mediates profound resistance to bisantrene.

Zhang XP, Ritke MK, Yalowich JC, Slovak ML, Ho JP, Collins KI, Annable T, Arceci RJ, Durr FE, Greenberger LM. Zhang XP, et al. Among authors: greenberger lm. Oncol Res. 1994;6(7):291-301. Oncol Res. 1994. PMID: 7865904

3

Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C.

Rabindran SK, He H, Singh M, Brown E, Collins KI, Annable T, Greenberger LM. Rabindran SK, et al. Among authors: greenberger lm. Cancer Res. 1998 Dec 15;58(24):5850-8. Cancer Res. 1998. PMID: 9865745

4

Novel multidrug resistance reversal agents.

Berger D, Citarella R, Dutia M, Greenberger L, Hallett W, Paul R, Powell D. Berger D, et al. J Med Chem. 1999 Jun 17;42(12):2145-61. doi: 10.1021/jm9804477. J Med Chem. 1999. PMID: 10377220

5

HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

Loganzo F, Discafani CM, Annable T, Beyer C, Musto S, Hari M, Tan X, Hardy C, Hernandez R, Baxter M, Singanallore T, Khafizova G, Poruchynsky MS, Fojo T, Nieman JA, Ayral-Kaloustian S, Zask A, Andersen RJ, Greenberger LM. Loganzo F, et al. Among authors: greenberger lm. Cancer Res. 2003 Apr 15;63(8):1838-45. Cancer Res. 2003. PMID: 12702571

6

Cells resistant to HTI-286 do not overexpress P-glycoprotein but have reduced drug accumulation and a point mutation in alpha-tubulin.

Loganzo F, Hari M, Annable T, Tan X, Morilla DB, Musto S, Zask A, Kaplan J, Minnick AA Jr, May MK, Ayral-Kaloustian S, Poruchynsky MS, Fojo T, Greenberger LM. Loganzo F, et al. Among authors: greenberger lm. Mol Cancer Ther. 2004 Oct;3(10):1319-27. Mol Cancer Ther. 2004. PMID: 15486199

7

Functional evidence that transmembrane 12 and the loop between transmembrane 11 and 12 form part of the drug-binding domain in P-glycoprotein encoded by MDR1.

Zhang X, Collins KI, Greenberger LM. Zhang X, et al. Among authors: greenberger lm. J Biol Chem. 1995 Mar 10;270(10):5441-8. doi: 10.1074/jbc.270.10.5441. J Biol Chem. 1995. PMID: 7890659 Free article.

8

A new antiestrogen, 2-(4-hydroxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1H-indol-5-ol hydrochloride (ERA-923), inhibits the growth of tamoxifen-sensitive and -resistant tumors and is devoid of uterotropic effects in mice and rats.

Greenberger LM, Annable T, Collins KI, Komm BS, Lyttle CR, Miller CP, Satyaswaroop PG, Zhang Y, Frost P. Greenberger LM, et al. Clin Cancer Res. 2001 Oct;7(10):3166-77. Clin Cancer Res. 2001. PMID: 11595711

9

MAC-321, a novel taxane with greater efficacy than paclitaxel and docetaxel in vitro and in vivo.

Sampath D, Discafani CM, Loganzo F, Beyer C, Liu H, Tan X, Musto S, Annable T, Gallagher P, Rios C, Greenberger LM. Sampath D, et al. Among authors: greenberger lm. Mol Cancer Ther. 2003 Sep;2(9):873-84. Mol Cancer Ther. 2003. PMID: 14555706

10

Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules.

Hari M, Loganzo F, Annable T, Tan X, Musto S, Morilla DB, Nettles JH, Snyder JP, Greenberger LM. Hari M, et al. Among authors: greenberger lm. Mol Cancer Ther. 2006 Feb;5(2):270-8. doi: 10.1158/1535-7163.MCT-05-0190. Mol Cancer Ther. 2006. PMID: 16505100

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