Dolan ME - Search Results

1

Pharmacokinetics and metabolism in rats of 2,4-diamino-6-benzyloxy-5- nitrosopyrimidine, an inactivator of O6-alkylguanine-DNA alkyltransferase.

Roy SK, Moschel RC, Dolan ME. Roy SK, et al. Among authors: dolan me. Drug Metab Dispos. 1996 Nov;24(11):1205-11. Drug Metab Dispos. 1996. PMID: 8937854

2

Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.

Friedman HS, Dolan ME, Moschel RC, Pegg AE, Felker GM, Rich J, Bigner DD, Schold SC Jr. Friedman HS, et al. Among authors: dolan me. J Natl Cancer Inst. 1992 Dec 16;84(24):1926-31. doi: 10.1093/jnci/84.24.1926. J Natl Cancer Inst. 1992. PMID: 1334154

3

Structural features of substituted purine derivatives compatible with depletion of human O6-alkylguanine-DNA alkyltransferase.

Moschel RC, McDougall MG, Dolan ME, Stine L, Pegg AE. Moschel RC, et al. Among authors: dolan me. J Med Chem. 1992 Nov 13;35(23):4486-91. doi: 10.1021/jm00101a028. J Med Chem. 1992. PMID: 1447749

4

Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.

Dolan ME, Mitchell RB, Mummert C, Moschel RC, Pegg AE. Dolan ME, et al. Cancer Res. 1991 Jul 1;51(13):3367-72. Cancer Res. 1991. PMID: 1647266

5

Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation.

Mitchell RB, Moschel RC, Dolan ME. Mitchell RB, et al. Among authors: dolan me. Cancer Res. 1992 Mar 1;52(5):1171-5. Cancer Res. 1992. PMID: 1737376

6

Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine.

Dolan ME, Pegg AE, Dumenco LL, Moschel RC, Gerson SL. Dolan ME, et al. Carcinogenesis. 1991 Dec;12(12):2305-9. doi: 10.1093/carcin/12.12.2305. Carcinogenesis. 1991. PMID: 1747932

7

Use of antibodies to human O6-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O6-benzylguanine or N-methyl-N'-nitro-N-nitrosoguanidine.

Pegg AE, Wiest L, Mummert C, Stine L, Moschel RC, Dolan ME. Pegg AE, et al. Among authors: dolan me. Carcinogenesis. 1991 Sep;12(9):1679-83. doi: 10.1093/carcin/12.9.1679. Carcinogenesis. 1991. PMID: 1893528

8

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.

Dolan ME, Moschel RC, Pegg AE. Dolan ME, et al. Proc Natl Acad Sci U S A. 1990 Jul;87(14):5368-72. doi: 10.1073/pnas.87.14.5368. Proc Natl Acad Sci U S A. 1990. PMID: 2164681 Free PMC article.

9

Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea.

Dolan ME, Stine L, Mitchell RB, Moschel RC, Pegg AE. Dolan ME, et al. Cancer Commun. 1990;2(11):371-7. doi: 10.3727/095535490820873985. Cancer Commun. 1990. PMID: 2242301

10

Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea.

Pegg AE, Swenn K, Chae MY, Dolan ME, Moschel RC. Pegg AE, et al. Among authors: dolan me. Biochem Pharmacol. 1995 Oct 12;50(8):1141-8. doi: 10.1016/0006-2952(95)00249-y. Biochem Pharmacol. 1995. PMID: 7488227

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