Das K - Search Results

1

Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant.

Das K, Ding J, Hsiou Y, Clark AD Jr, Moereels H, Koymans L, Andries K, Pauwels R, Janssen PA, Boyer PL, Clark P, Smith RH Jr, Kroeger Smith MB, Michejda CJ, Hughes SH, Arnold E. Das K, et al. J Mol Biol. 1996 Dec 20;264(5):1085-100. doi: 10.1006/jmbi.1996.0698. J Mol Biol. 1996. PMID: 9000632

2

Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor alpha-APA R 95845 at 2.8 A resolution.

Ding J, Das K, Tantillo C, Zhang W, Clark AD Jr, Jessen S, Lu X, Hsiou Y, Jacobo-Molina A, Andries K, et al. Ding J, et al. Among authors: das k. Structure. 1995 Apr 15;3(4):365-79. doi: 10.1016/s0969-2126(01)00168-x. Structure. 1995. PMID: 7542140 Free article.

3

Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors.

Ding J, Das K, Moereels H, Koymans L, Andries K, Janssen PA, Hughes SH, Arnold E. Ding J, et al. Among authors: das k. Nat Struct Biol. 1995 May;2(5):407-15. doi: 10.1038/nsb0595-407. Nat Struct Biol. 1995. PMID: 7545077

4

Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms.

Hsiou Y, Ding J, Das K, Clark AD Jr, Hughes SH, Arnold E. Hsiou Y, et al. Among authors: das k. Structure. 1996 Jul 15;4(7):853-60. doi: 10.1016/s0969-2126(96)00091-3. Structure. 1996. PMID: 8805568 Free article.

5

Targeting HIV reverse transcriptase for anti-AIDS drug design: structural and biological considerations for chemotherapeutic strategies.

Arnold E, Das K, Ding J, Yadav PN, Hsiou Y, Boyer PL, Hughes SH. Arnold E, et al. Among authors: das k. Drug Des Discov. 1996 Apr;13(3-4):29-47. Drug Des Discov. 1996. PMID: 8874042 Review.

6

Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance.

Hsiou Y, Das K, Ding J, Clark AD Jr, Kleim JP, Rösner M, Winkler I, Riess G, Hughes SH, Arnold E. Hsiou Y, et al. Among authors: das k. J Mol Biol. 1998 Nov 27;284(2):313-23. doi: 10.1006/jmbi.1998.2171. J Mol Biol. 1998. PMID: 9813120

7

Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution.

Ding J, Das K, Hsiou Y, Sarafianos SG, Clark AD Jr, Jacobo-Molina A, Tantillo C, Hughes SH, Arnold E. Ding J, et al. Among authors: das k. J Mol Biol. 1998 Dec 11;284(4):1095-111. doi: 10.1006/jmbi.1998.2208. J Mol Biol. 1998. PMID: 9837729

8

Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site.

Sarafianos SG, Das K, Ding J, Boyer PL, Hughes SH, Arnold E. Sarafianos SG, et al. Among authors: das k. Chem Biol. 1999 May;6(5):R137-46. doi: 10.1016/s1074-5521(99)80071-4. Chem Biol. 1999. PMID: 10322129 Review.

9

Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids.

Sarafianos SG, Das K, Clark AD Jr, Ding J, Boyer PL, Hughes SH, Arnold E. Sarafianos SG, et al. Among authors: das k. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10027-32. doi: 10.1073/pnas.96.18.10027. Proc Natl Acad Sci U S A. 1999. PMID: 10468556 Free PMC article.

10

A mutation in human immunodeficiency virus type 1 protease, N88S, that causes in vitro hypersensitivity to amprenavir.

Ziermann R, Limoli K, Das K, Arnold E, Petropoulos CJ, Parkin NT. Ziermann R, et al. Among authors: das k. J Virol. 2000 May;74(9):4414-9. doi: 10.1128/jvi.74.9.4414-4419.2000. J Virol. 2000. PMID: 10756056 Free PMC article.

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