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Page 1
Molecular mechanisms of fibrillogenesis and the protective role of amyloid P component: two possible avenues for therapy.
Pepys MB, Tennent GA, Booth DR, Bellotti V, Lovat LB, Tan SY, Persey MR, Hutchinson WL, Booth SE, Madhoo S, Soutar AK, Hawkins PN, Van Zyl-Smit R, Campistol JM, Fraser PE, Radford SE, Robinson CV, Sunde M, Serpell LC, Blake CC. Pepys MB, et al. Among authors: fraser pe. Ciba Found Symp. 1996;199:73-81; discussion 81-9. doi: 10.1002/9780470514924.ch6. Ciba Found Symp. 1996. PMID: 8915605
The protofilament substructure of amyloid fibrils.
Serpell LC, Sunde M, Benson MD, Tennent GA, Pepys MB, Fraser PE. Serpell LC, et al. Among authors: fraser pe. J Mol Biol. 2000 Jul 28;300(5):1033-9. doi: 10.1006/jmbi.2000.3908. J Mol Biol. 2000. PMID: 10903851
X-ray fiber diffraction of amyloid fibrils.
Serpell LC, Fraser PE, Sunde M. Serpell LC, et al. Among authors: fraser pe. Methods Enzymol. 1999;309:526-36. doi: 10.1016/s0076-6879(99)09036-9. Methods Enzymol. 1999. PMID: 10507046 No abstract available.
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice.
Citron M, Westaway D, Xia W, Carlson G, Diehl T, Levesque G, Johnson-Wood K, Lee M, Seubert P, Davis A, Kholodenko D, Motter R, Sherrington R, Perry B, Yao H, Strome R, Lieberburg I, Rommens J, Kim S, Schenk D, Fraser P, St George Hyslop P, Selkoe DJ. Citron M, et al. Nat Med. 1997 Jan;3(1):67-72. doi: 10.1038/nm0197-67. Nat Med. 1997. PMID: 8986743
Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.
McLaurin J, Cecal R, Kierstead ME, Tian X, Phinney AL, Manea M, French JE, Lambermon MH, Darabie AA, Brown ME, Janus C, Chishti MA, Horne P, Westaway D, Fraser PE, Mount HT, Przybylski M, St George-Hyslop P. McLaurin J, et al. Among authors: fraser pe. Nat Med. 2002 Nov;8(11):1263-9. doi: 10.1038/nm790. Epub 2002 Oct 15. Nat Med. 2002. PMID: 12379850
254 results