Two metal-binding sites in a lead ribozyme bound to competitively by Pb2+ and Mg2+--induced structural changes as revealed by NMR.
Katahira M, Kim MH, Sugiyama T, Nishimura Y, Uesugi S.
Katahira M, et al. Among authors: uesugi s.
Eur J Biochem. 1998 Aug 1;255(3):727-33. doi: 10.1046/j.1432-1327.1998.2550727.x.
Eur J Biochem. 1998.
PMID: 9738914
Free article.
We reported recently that a lead ribozyme with modified bases cleaved at an additional site at high Pb2+ concentrations (>0.1 mM), and that the cleavage at a canonical site was enhanced nearly fourfold at the optimum combination of Pb2+ and Mg2+ concentrations [Kim, M. H., Kat …
We reported recently that a lead ribozyme with modified bases cleaved at an additional site at high Pb2+ concentrations (>0.1 mM), and th …