Rösner M - Search Results

1

In vitro selection for different mutational patterns in the HIV-1 reverse transcriptase using high and low selective pressure of the nonnucleoside reverse transcriptase inhibitor HBY 097.

Kleim JP, Winkler I, Rösner M, Kirsch R, Rübsamen-Waigmann H, Paessens A, Riess G. Kleim JP, et al. Among authors: rosner m. Virology. 1997 Apr 28;231(1):112-8. doi: 10.1006/viro.1997.8513. Virology. 1997. PMID: 9143309 Free article.

2

Activity of a novel quinoxaline derivative against human immunodeficiency virus type 1 reverse transcriptase and viral replication.

Kleim JP, Bender R, Billhardt UM, Meichsner C, Riess G, Rösner M, Winkler I, Paessens A. Kleim JP, et al. Among authors: rosner m. Antimicrob Agents Chemother. 1993 Aug;37(8):1659-64. doi: 10.1128/AAC.37.8.1659. Antimicrob Agents Chemother. 1993. PMID: 7692812 Free PMC article.

3

Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-->Val or Ile and Val-75-->Leu or Ile) HIV-1 mutants.

Kleim JP, Rösner M, Winkler I, Paessens A, Kirsch R, Hsiou Y, Arnold E, Riess G. Kleim JP, et al. Among authors: rosner m. Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):34-8. doi: 10.1073/pnas.93.1.34. Proc Natl Acad Sci U S A. 1996. PMID: 8552634 Free PMC article.

4

Preclinical evaluation of HBY 097, a new nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 replication.

Kleim JP, Bender R, Kirsch R, Meichsner C, Paessens A, Rösner M, Rübsamen-Waigmann H, Kaiser R, Wichers M, Schneweis KE, et al. Kleim JP, et al. Among authors: rosner m. Antimicrob Agents Chemother. 1995 Oct;39(10):2253-7. doi: 10.1128/AAC.39.10.2253. Antimicrob Agents Chemother. 1995. PMID: 8619578 Free PMC article.

5

Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance.

Hsiou Y, Das K, Ding J, Clark AD Jr, Kleim JP, Rösner M, Winkler I, Riess G, Hughes SH, Arnold E. Hsiou Y, et al. Among authors: rosner m. J Mol Biol. 1998 Nov 27;284(2):313-23. doi: 10.1006/jmbi.1998.2171. J Mol Biol. 1998. PMID: 9813120

6

Antiviral activity and pharmacokinetics of HOE 602, an acyclic nucleoside, in animal models.

Winkler I, Winkelmann E, Scholl T, Rösner M, Jähne G, Helsberg M. Winkler I, et al. Among authors: rosner m. Antiviral Res. 1990 Aug;14(2):61-73. doi: 10.1016/0166-3542(90)90044-8. Antiviral Res. 1990. PMID: 2177317

7

The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance.

Hsiou Y, Ding J, Das K, Clark AD Jr, Boyer PL, Lewi P, Janssen PA, Kleim JP, Rösner M, Hughes SH, Arnold E. Hsiou Y, et al. Among authors: rosner m. J Mol Biol. 2001 Jun 1;309(2):437-45. doi: 10.1006/jmbi.2001.4648. J Mol Biol. 2001. PMID: 11371163

8

New prodrugs of acyclic nucleosides with antiviral activity.

Winkelmann E, Winkler I, Rolly H, Rösner M, Jähne G. Winkelmann E, et al. Among authors: rosner m. Arzneimittelforschung. 1988 Nov;38(11):1545-8. Arzneimittelforschung. 1988. PMID: 3265058

9

A substituted thieno[3.4-d]imidazole versus substituted benzimidazoles as H+, K+-ATPase inhibitors.

Herling AW, Bickel M, Lang HJ, Weidmann K, Rösner M, Metzger H, Rippel R, Nimmesgern H, Scheunemann KH. Herling AW, et al. Among authors: rosner m. Pharmacology. 1988;36(5):289-97. doi: 10.1159/000138397. Pharmacology. 1988. PMID: 2841691

10

Raf kinase inhibitory protein function is regulated via a flexible pocket and novel phosphorylation-dependent mechanism.

Granovsky AE, Clark MC, McElheny D, Heil G, Hong J, Liu X, Kim Y, Joachimiak G, Joachimiak A, Koide S, Rosner MR. Granovsky AE, et al. Mol Cell Biol. 2009 Mar;29(5):1306-20. doi: 10.1128/MCB.01271-08. Epub 2008 Dec 22. Mol Cell Biol. 2009. PMID: 19103740 Free PMC article.

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