Okun I - Search Results

1

Discovery of TBC11251, a potent, long acting, orally active endothelin receptor-A selective antagonist.

Wu C, Chan MF, Stavros F, Raju B, Okun I, Mong S, Keller KM, Brock T, Kogan TP, Dixon RA. Wu C, et al. Among authors: okun i. J Med Chem. 1997 May 23;40(11):1690-7. doi: 10.1021/jm9700068. J Med Chem. 1997. PMID: 9171878

2

Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening.

Chan MF, Okun I, Stavros FL, Hwang E, Wolff ME, Balaji VN. Chan MF, et al. Among authors: okun i. Biochem Biophys Res Commun. 1994 May 30;201(1):228-34. doi: 10.1006/bbrc.1994.1693. Biochem Biophys Res Commun. 1994. PMID: 8198578

3

Structure-activity relationships of N2-aryl-3-(isoxazolylsulfamoyl)-2-thiophenecarboxamides as selective endothelin receptor-A antagonists.

Wu C, Chan MF, Stavros F, Raju B, Okun I, Castillo RS. Wu C, et al. Among authors: okun i. J Med Chem. 1997 May 23;40(11):1682-9. doi: 10.1021/jm9608366. J Med Chem. 1997. PMID: 9171877

4

The discovery and structure-activity relationships of nonpeptide, low molecular weight antagonists selective for the endothelin ET(B) receptor.

Chan MF, Kois A, Verner EJ, Raju BG, Castillo RS, Wu C, Okun I, Stavros FD, Balaji VN. Chan MF, et al. Among authors: okun i. Bioorg Med Chem. 1998 Dec;6(12):2301-16. doi: 10.1016/s0968-0896(98)80010-2. Bioorg Med Chem. 1998. PMID: 9925292

5

COS-7 cells stably transfected to express the human ETB receptor provide a useful screen for endothelin receptor antagonists.

Stavros FD, Hasel KW, Okun I, Baldwin J, Freriks K. Stavros FD, et al. Among authors: okun i. J Cardiovasc Pharmacol. 1993;22 Suppl 8:S34-7. doi: 10.1097/00005344-199322008-00011. J Cardiovasc Pharmacol. 1993. PMID: 7509982

6

(3-Phenylsulfonylcycloalkano[e and d]pyrazolo[1,5-a]pyrimidin-2-yl)amines: potent and selective antagonists of the serotonin 5-HT6 receptor.

Ivachtchenko AV, Dmitriev DE, Golovina ES, Kadieva MG, Koryakova AG, Kysil VM, Mitkin OD, Okun IM, Tkachenko SE, Vorobiev AA. Ivachtchenko AV, et al. J Med Chem. 2010 Jul 22;53(14):5186-96. doi: 10.1021/jm100350r. J Med Chem. 2010. PMID: 20560595

7

Synthesis and biological study of 3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines as potent and selective serotonin 5-HT6 receptor antagonists.

Ivachtchenko AV, Golovina ES, Kadieva MG, Koryakova AG, Kovalenko SM, Mitkin OD, Okun IM, Ravnyeyko IM, Tkachenko SE, Zaremba OV. Ivachtchenko AV, et al. Bioorg Med Chem. 2010 Jul 15;18(14):5282-90. doi: 10.1016/j.bmc.2010.05.051. Epub 2010 May 24. Bioorg Med Chem. 2010. PMID: 20541425

8

Pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. Synthesis and SAR of 2-substituted 4-methyl-8-(morpholine-4-sulfonyl)-pyrrolo[3,4-c]quinoline-1,3-diones.

Kravchenko DV, Kysil VM, Tkachenko SE, Maliarchouk S, Okun IM, Ivachtchenko AV. Kravchenko DV, et al. Eur J Med Chem. 2005 Dec;40(12):1377-83. doi: 10.1016/j.ejmech.2005.07.011. Epub 2005 Sep 15. Eur J Med Chem. 2005. PMID: 16169127

9

8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists.

Ivachtchenko AV, Mitkin OD, Tkachenko SE, Okun IM, Kysil VM. Ivachtchenko AV, et al. Eur J Med Chem. 2010 Feb;45(2):782-9. doi: 10.1016/j.ejmech.2009.10.035. Epub 2009 Oct 31. Eur J Med Chem. 2010. PMID: 19939513

10

Synthesis and structure-activity relationship (SAR) of (5,7-disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as potent serotonin 5-HT(6) receptor (5-HT(6)R) antagonists.

Ivachtchenko AV, Golovina ES, Kadieva MG, Kysil VM, Mitkin OD, Tkachenko SE, Okun IM. Ivachtchenko AV, et al. Among authors: okun im. J Med Chem. 2011 Dec 8;54(23):8161-73. doi: 10.1021/jm201079g. Epub 2011 Nov 10. J Med Chem. 2011. PMID: 22029285

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