Bruzik KS - Search Results

1

Phosphatidylinositol-specific phospholipase C: kinetic and stereochemical evidence for an interaction between arginine-69 and the phosphate group of phosphatidylinositol.

Hondal RJ, Riddle SR, Kravchuk AV, Zhao Z, Liao H, Bruzik KS, Tsai MD. Hondal RJ, et al. Among authors: bruzik ks. Biochemistry. 1997 Jun 3;36(22):6633-42. doi: 10.1021/bi962866g. Biochemistry. 1997. PMID: 9184143

2

A novel calcium-dependent bacterial phosphatidylinositol-specific phospholipase C displaying unprecedented magnitudes of thio effect, inverse thio effect, and stereoselectivity.

Zhao L, Liu Y, Bruzik KS, Tsai MD. Zhao L, et al. Among authors: bruzik ks. J Am Chem Soc. 2003 Jan 8;125(1):22-3. doi: 10.1021/ja029019n. J Am Chem Soc. 2003. PMID: 12515492

3

Engineering a catalytic metal binding site into a calcium-independent phosphatidylinositol-specific phospholipase C leads to enhanced stereoselectivity.

Kravchuk AV, Zhao L, Bruzik KS, Tsai MD. Kravchuk AV, et al. Among authors: bruzik ks. Biochemistry. 2003 Mar 4;42(8):2422-30. doi: 10.1021/bi0271953. Biochemistry. 2003. PMID: 12600209

4

Phospholipids chiral at phosphorus. Synthesis of chiral phosphatidylcholine and stereochemistry of phospholipase D.

Bruzik K, Tsai MD. Bruzik K, et al. Biochemistry. 1984 Apr 10;23(8):1656-61. doi: 10.1021/bi00303a012. Biochemistry. 1984. PMID: 6722117

5

Phospholipids chiral at phosphorus. Stereochemical mechanism for the formation of inositol 1-phosphate catalyzed by phosphatidylinositol-specific phospholipase C.

Bruzik KS, Morocho AM, Jhon DY, Rhee SG, Tsai MD. Bruzik KS, et al. Biochemistry. 1992 Jun 9;31(22):5183-93. doi: 10.1021/bi00137a014. Biochemistry. 1992. PMID: 1318746

6

Are D- and L-chiro-phosphoinositides substrates of phosphatidylinositol-specific phospholipase C?

Bruzik KS, Hakeem AA, Tsai MD. Bruzik KS, et al. Biochemistry. 1994 Jul 12;33(27):8367-74. doi: 10.1021/bi00193a026. Biochemistry. 1994. PMID: 8031771

7

Mechanism of phosphatidylinositol-specific phospholipase C: a unified view of the mechanism of catalysis.

Hondal RJ, Zhao Z, Kravchuk AV, Liao H, Riddle SR, Yue X, Bruzik KS, Tsai MD. Hondal RJ, et al. Among authors: bruzik ks. Biochemistry. 1998 Mar 31;37(13):4568-80. doi: 10.1021/bi972646i. Biochemistry. 1998. PMID: 9521777

8

Involvement of the Arg-Asp-His catalytic triad in enzymatic cleavage of the phosphodiester bond.

Kubiak RJ, Yue X, Hondal RJ, Mihai C, Tsai MD, Bruzik KS. Kubiak RJ, et al. Among authors: bruzik ks. Biochemistry. 2001 May 8;40(18):5422-32. doi: 10.1021/bi002371y. Biochemistry. 2001. PMID: 11331006

9

Mechanism of phosphatidylinositol-specific phospholipase C: origin of unusually high nonbridging thio effects.

Kravchuk AV, Zhao L, Kubiak RJ, Bruzik KS, Tsai MD. Kravchuk AV, et al. Among authors: bruzik ks. Biochemistry. 2001 May 8;40(18):5433-9. doi: 10.1021/bi002372q. Biochemistry. 2001. PMID: 11331007

10

Unique catalytic mechanism of phosphatidylinositol-specific phospholipase C from Streptomyces antibioticus.

Bai C, Zhao L, Tsai MD, Bruzik KS. Bai C, et al. Among authors: bruzik ks. J Am Chem Soc. 2010 Feb 3;132(4):1210-1. doi: 10.1021/ja908285h. J Am Chem Soc. 2010. PMID: 20052980 Free PMC article.

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