Severin JM - Search Results

1

Solution structure of an rRNA methyltransferase (ErmAM) that confers macrolide-lincosamide-streptogramin antibiotic resistance.

Yu L, Petros AM, Schnuchel A, Zhong P, Severin JM, Walter K, Holzman TF, Fesik SW. Yu L, et al. Among authors: severin jm. Nat Struct Biol. 1997 Jun;4(6):483-9. doi: 10.1038/nsb0697-483. Nat Struct Biol. 1997. PMID: 9187657

2

Three-dimensional structure of the FK506 binding protein/ascomycin complex in solution by heteronuclear three- and four-dimensional NMR.

Meadows RP, Nettesheim DG, Xu RX, Olejniczak ET, Petros AM, Holzman TF, Severin J, Gubbins E, Smith H, Fesik SW. Meadows RP, et al. Biochemistry. 1993 Jan 26;32(3):754-65. doi: 10.1021/bi00054a004. Biochemistry. 1993. PMID: 7678499

3

Design of adenosine kinase inhibitors from the NMR-based screening of fragments.

Hajduk PJ, Gomtsyan A, Didomenico S, Cowart M, Bayburt EK, Solomon L, Severin J, Smith R, Walter K, Holzman TF, Stewart A, McGaraughty S, Jarvis MF, Kowaluk EA, Fesik SW. Hajduk PJ, et al. J Med Chem. 2000 Dec 14;43(25):4781-6. doi: 10.1021/jm000373a. J Med Chem. 2000. PMID: 11123986

4

High-level expression of recombinant human FK-binding protein from a fusion precursor.

Edalji R, Pilot-Matias TJ, Pratt SD, Egan DA, Severin JM, Gubbins EG, Petros AM, Fesik SW, Burres NS, Holzman TF. Edalji R, et al. Among authors: severin jm. J Protein Chem. 1992 Jun;11(3):213-23. doi: 10.1007/BF01024859. J Protein Chem. 1992. PMID: 1382438

5

Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.

Huth JR, Park C, Petros AM, Kunzer AR, Wendt MD, Wang X, Lynch CL, Mack JC, Swift KM, Judge RA, Chen J, Richardson PL, Jin S, Tahir SK, Matayoshi ED, Dorwin SA, Ladror US, Severin JM, Walter KA, Bartley DM, Fesik SW, Elmore SW, Hajduk PJ. Huth JR, et al. Among authors: severin jm. Chem Biol Drug Des. 2007 Jul;70(1):1-12. doi: 10.1111/j.1747-0285.2007.00535.x. Chem Biol Drug Des. 2007. PMID: 17630989

6

1H, 13C and 15N backbone assignments of cyclophilin when bound to cyclosporin A (CsA) and preliminary structural characterization of the CsA binding site.

Neri P, Meadows R, Gemmecker G, Olejniczak E, Nettesheim D, Logan T, Simmer R, Helfrich R, Holzman T, Severin J, et al. Neri P, et al. FEBS Lett. 1991 Dec 2;294(1-2):81-8. doi: 10.1016/0014-5793(91)81348-c. FEBS Lett. 1991. PMID: 1743298 Free article.

7

Identification of novel inhibitors of urokinase via NMR-based screening.

Hajduk PJ, Boyd S, Nettesheim D, Nienaber V, Severin J, Smith R, Davidson D, Rockway T, Fesik SW. Hajduk PJ, et al. J Med Chem. 2000 Oct 19;43(21):3862-6. doi: 10.1021/jm0002228. J Med Chem. 2000. PMID: 11052791

8

The structure of VanX reveals a novel amino-dipeptidase involved in mediating transposon-based vancomycin resistance.

Bussiere DE, Pratt SD, Katz L, Severin JM, Holzman T, Park CH. Bussiere DE, et al. Among authors: severin jm. Mol Cell. 1998 Jul;2(1):75-84. doi: 10.1016/s1097-2765(00)80115-x. Mol Cell. 1998. PMID: 9702193 Free article.

9

A high throughput fluorescent assay for measuring the activity of fatty acid amide hydrolase.

Kage KL, Richardson PL, Traphagen L, Severin J, Pereda-Lopez A, Lubben T, Davis-Taber R, Vos MH, Bartley D, Walter K, Harlan J, Solomon L, Warrior U, Holzman TF, Faltynek C, Surowy CS, Scott VE. Kage KL, et al. J Neurosci Methods. 2007 Mar 30;161(1):47-54. doi: 10.1016/j.jneumeth.2006.10.006. Epub 2006 Nov 2. J Neurosci Methods. 2007. PMID: 17083980

10

Abrogation of G2 checkpoint specifically sensitize p53 defective cells to cancer chemotherapeutic agents.

Luo Y, Rockow-Magnone SK, Joseph MK, Bradner J, Butler CC, Tahir SK, Han EK, Ng SC, Severin JM, Gubbins EJ, Reilly RM, Rueter A, Simmer RL, Holzman TF, Giranda VL. Luo Y, et al. Among authors: severin jm. Anticancer Res. 2001 Jan-Feb;21(1A):23-8. Anticancer Res. 2001. PMID: 11299740

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