Saharinen P - Search Results

1

Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a JAK1-dependent pathway.

Stancato LF, Sakatsume M, David M, Dent P, Dong F, Petricoin EF, Krolewski JJ, Silvennoinen O, Saharinen P, Pierce J, Marshall CJ, Sturgill T, Finbloom DS, Larner AC. Stancato LF, et al. Among authors: saharinen p. Mol Cell Biol. 1997 Jul;17(7):3833-40. doi: 10.1128/MCB.17.7.3833. Mol Cell Biol. 1997. PMID: 9199317 Free PMC article.

2

Interferon gamma activation of Raf-1 is Jak1-dependent and p21ras-independent.

Sakatsume M, Stancato LF, David M, Silvennoinen O, Saharinen P, Pierce J, Larner AC, Finbloom DS. Sakatsume M, et al. Among authors: saharinen p. J Biol Chem. 1998 Jan 30;273(5):3021-6. doi: 10.1074/jbc.273.5.3021. J Biol Chem. 1998. PMID: 9446616 Free article.

3

The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction.

Saharinen P, Silvennoinen O. Saharinen P, et al. J Biol Chem. 2002 Dec 6;277(49):47954-63. doi: 10.1074/jbc.M205156200. Epub 2002 Sep 25. J Biol Chem. 2002. PMID: 12351625 Free article.

4

Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain.

Saharinen P, Vihinen M, Silvennoinen O. Saharinen P, et al. Mol Biol Cell. 2003 Apr;14(4):1448-59. doi: 10.1091/mbc.e02-06-0342. Mol Biol Cell. 2003. PMID: 12686600 Free PMC article.

5

Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state.

Kurzer JH, Saharinen P, Silvennoinen O, Carter-Su C. Kurzer JH, et al. Among authors: saharinen p. Mol Cell Biol. 2006 Sep;26(17):6381-94. doi: 10.1128/MCB.00570-06. Mol Cell Biol. 2006. PMID: 16914724 Free PMC article.

6

Regulation of the Jak2 tyrosine kinase by its pseudokinase domain.

Saharinen P, Takaluoma K, Silvennoinen O. Saharinen P, et al. Mol Cell Biol. 2000 May;20(10):3387-95. doi: 10.1128/MCB.20.10.3387-3395.2000. Mol Cell Biol. 2000. PMID: 10779328 Free PMC article.

7

Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.

Ungureanu D, Saharinen P, Junttila I, Hilton DJ, Silvennoinen O. Ungureanu D, et al. Among authors: saharinen p. Mol Cell Biol. 2002 May;22(10):3316-26. doi: 10.1128/MCB.22.10.3316-3326.2002. Mol Cell Biol. 2002. PMID: 11971965 Free PMC article.

8

The Janus kinases (Jaks).

Yamaoka K, Saharinen P, Pesu M, Holt VE 3rd, Silvennoinen O, O'Shea JJ. Yamaoka K, et al. Among authors: saharinen p. Genome Biol. 2004;5(12):253. doi: 10.1186/gb-2004-5-12-253. Epub 2004 Nov 30. Genome Biol. 2004. PMID: 15575979 Free PMC article. Review.

9

The Bmx tyrosine kinase induces activation of the Stat signaling pathway, which is specifically inhibited by protein kinase Cdelta.

Saharinen P, Ekman N, Sarvas K, Parker P, Alitalo K, Silvennoinen O. Saharinen P, et al. Blood. 1997 Dec 1;90(11):4341-53. Blood. 1997. PMID: 9373245 Free article.

10

Regulation of Jak2 tyrosine kinase by protein kinase C during macrophage differentiation of IL-3-dependent myeloid progenitor cells.

Kovanen PE, Junttila I, Takaluoma K, Saharinen P, Valmu L, Li W, Silvennoinen O. Kovanen PE, et al. Among authors: saharinen p. Blood. 2000 Mar 1;95(5):1626-32. Blood. 2000. PMID: 10688817 Free article.

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