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60 results

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Page 1
Potent tetracyclic guanine inhibitors of PDE1 and PDE5 cyclic guanosine monophosphate phosphodiesterases with oral antihypertensive activity.
Ahn HS, Bercovici A, Boykow G, Bronnenkant A, Chackalamannil S, Chow J, Cleven R, Cook J, Czarniecki M, Domalski C, Fawzi A, Green M, Gündes A, Ho G, Laudicina M, Lindo N, Ma K, Manna M, McKittrick B, Mirzai B, Nechuta T, Neustadt B, Puchalski C, Pula K, Zhang H, et al. Ahn HS, et al. Among authors: chackalamannil s. J Med Chem. 1997 Jul 4;40(14):2196-210. doi: 10.1021/jm9608467. J Med Chem. 1997. PMID: 9216839
Potent, low molecular weight thrombin receptor antagonists.
Chackalamannil S, Doller D, Eagen K, Czarniecki M, Ahn HS, Foster CJ, Boykow G. Chackalamannil S, et al. Bioorg Med Chem Lett. 2001 Nov 5;11(21):2851-3. doi: 10.1016/s0960-894x(01)00555-8. Bioorg Med Chem Lett. 2001. PMID: 11597414
Potent non-peptide thrombin receptor antagonists.
Chackalamannil S, Ahn HS, Xia Y, Doller D, Foster C. Chackalamannil S, et al. Curr Med Chem Cardiovasc Hematol Agents. 2003 Mar;1(1):37-45. doi: 10.2174/1568016033356706. Curr Med Chem Cardiovasc Hematol Agents. 2003. PMID: 15317289 Review.
Discovery and synthesis of a novel series of quinoline-based thrombin receptor (PAR-1) antagonists.
Clasby MC, Chackalamannil S, Czarniecki M, Doller D, Eagen K, Greenlee WJ, Lin Y, Tsai H, Xia Y, Ahn HS, Agans-Fantuzzi J, Boykow G, Chintala M, Foster C, Bryant M, Lau J. Clasby MC, et al. Among authors: chackalamannil s. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1544-8. doi: 10.1016/j.bmcl.2005.12.042. Epub 2005 Dec 27. Bioorg Med Chem Lett. 2006. PMID: 16380251
Metabolism-based identification of a potent thrombin receptor antagonist.
Clasby MC, Chackalamannil S, Czarniecki M, Doller D, Eagen K, Greenlee W, Kao G, Lin Y, Tsai H, Xia Y, Ahn HS, Agans-Fantuzzi J, Boykow G, Chintala M, Foster C, Smith-Torhan A, Alton K, Bryant M, Hsieh Y, Lau J, Palamanda J. Clasby MC, et al. Among authors: chackalamannil s. J Med Chem. 2007 Jan 11;50(1):129-38. doi: 10.1021/jm061043e. J Med Chem. 2007. PMID: 17201416
Himbacine derived thrombin receptor antagonists: discovery of a new tricyclic core.
Clasby MC, Chackalamannil S, Czarniecki M, Doller D, Eagen K, Greenlee WJ, Lin Y, Tagat JR, Tsai H, Xia Y, Ahn HS, Agans-Fantuzzi J, Boykow G, Chintala M, Hsieh Y, McPhail AT. Clasby MC, et al. Among authors: chackalamannil s. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3647-51. doi: 10.1016/j.bmcl.2007.04.061. Epub 2007 Apr 25. Bioorg Med Chem Lett. 2007. PMID: 17490877
Heterotricyclic himbacine analogs as potent, orally active thrombin receptor (protease activated receptor-1) antagonists.
Chelliah MV, Chackalamannil S, Xia Y, Eagen K, Clasby MC, Gao X, Greenlee W, Ahn HS, Agans-Fantuzzi J, Boykow G, Hsieh Y, Bryant M, Palamanda J, Chan TM, Hesk D, Chintala M. Chelliah MV, et al. Among authors: chackalamannil s. J Med Chem. 2007 Oct 18;50(21):5147-60. doi: 10.1021/jm070704k. Epub 2007 Sep 14. J Med Chem. 2007. PMID: 17854166
60 results