Cheng LL - Search Results

1

Position three in vasopressin antagonist tolerates conformationally restricted and aromatic amino acid substitutions: a striking contrast with vasopressin agonists.

Manning M, Cheng LL, Stoev S, Klis W, Nawrocka E, Olma A, Sawyer WH, Wo NC, Chan WY. Manning M, et al. Among authors: cheng ll. J Pept Sci. 1997 Jan-Feb;3(1):31-46. doi: 10.1002/(sici)1099-1387(199701)3:1<31::aid-psc82>3.0.co;2-y. J Pept Sci. 1997. PMID: 9230469

2

Design of peptide oxytocin antagonists with strikingly higher affinities and selectivities for the human oxytocin receptor than atosiban.

Manning M, Cheng LL, Stoev S, Wo NC, Chan WY, Szeto HH, Durroux T, Mouillac B, Barberis C. Manning M, et al. Among authors: cheng ll. J Pept Sci. 2005 Oct;11(10):593-608. doi: 10.1002/psc.667. J Pept Sci. 2005. PMID: 15880385

3

Position 4 analogues of [deamino-Cys(1)] arginine vasopressin exhibit striking species differences for human and rat V(2)/V(1b) receptor selectivity.

Guillon G, Pena A, Murat B, Derick S, Trueba M, Ventura MA, Szeto HH, Wo N, Stoev S, Cheng LL, Manning M. Guillon G, et al. Among authors: cheng ll. J Pept Sci. 2006 Mar;12(3):190-8. doi: 10.1002/psc.710. J Pept Sci. 2006. PMID: 16130178

Furthermore, peptides 1-4 exhibit high selectivities for the human V(1b) receptor with respect to the V(1a), V(2) and OT receptors and, with d[Cha(4)]AVP, in functional tests, are the first high affinity selective agonists for the human V(1b) receptor (Cheng LL et a …

Furthermore, peptides 1-4 exhibit high selectivities for the human V(1b) receptor with respect to the V(1a), V(2) and OT receptors and, with …

4

Design and synthesis of potent, highly selective vasopressin hypotensive agonists.

Stoev S, Cheng LL, Manning M, Wo NC, Szeto HH. Stoev S, et al. Among authors: cheng ll. J Pept Sci. 2006 Sep;12(9):592-604. doi: 10.1002/psc.756. J Pept Sci. 2006. PMID: 16625682

5

Potent V2/V1a vasopressin antagonists with C-terminal ethylenediamine-linked retro-amino acids.

Manning M, Przybylski J, Grzonka Z, Nawrocka E, Lammek B, Misicka A, Cheng LL, Chan WY, Wo NC, Sawyer WH. Manning M, et al. Among authors: cheng ll. J Med Chem. 1992 Oct 16;35(21):3895-904. doi: 10.1021/jm00099a018. J Med Chem. 1992. PMID: 1433200

6

Solid-phase synthesis of 16 potent (selective and nonselective) in vivo antagonists of oxytocin.

Manning M, Kruszynski M, Bankowski K, Olma A, Lammek B, Cheng LL, Klis WA, Seto J, Haldar J, Sawyer WH. Manning M, et al. Among authors: cheng ll. J Med Chem. 1989 Feb;32(2):382-91. doi: 10.1021/jm00122a016. J Med Chem. 1989. PMID: 2913298

7

C-terminal deletions in agonistic and antagonistic analogues of vasopressin that improve their specificities for antidiuretic (V2) and vasopressor (V1) receptors.

Manning M, Misicka A, Olma A, Klis WA, Bankowski K, Nawrocka E, Kruszynski M, Kolodziejczyk A, Cheng LL, Seto J, et al. Manning M, et al. Among authors: cheng ll. J Med Chem. 1987 Dec;30(12):2245-52. doi: 10.1021/jm00395a012. J Med Chem. 1987. PMID: 2960812

8

Effects of a D-Cys6/L-Cys6 interchange in nonselective and selective vasopressin and oxytocin antagonists.

Manning M, Cheng LL, Klis WA, Balaspiri L, Olma A, Sawyer WH, Wo NC, Chan WY. Manning M, et al. Among authors: cheng ll. J Med Chem. 1995 May 12;38(10):1762-9. doi: 10.1021/jm00010a020. J Med Chem. 1995. PMID: 7752199

9

Advances in the design of selective antagonists, potential tocolytics, and radioiodinated ligands for oxytocin receptors.

Manning M, Cheng LL, Klis WA, Stoev S, Przybylski J, Bankowski K, Sawyer WH, Barberis C, Chan WY. Manning M, et al. Among authors: cheng ll. Adv Exp Med Biol. 1995;395:559-83. Adv Exp Med Biol. 1995. PMID: 8714021 Review.

10

An exploration of the effects of L- and D-tetrahydroisoquinoline-3-carboxylic acid substitutions at positions 2, 3 and 7 in cyclic and linear antagonists of vasopressin and oxytocin and at position 3 in arginine vasopressin.

Manning M, Cheng LL, Stoev S, Bankowski K, Przybyiski J, Klis WA, Sawyer WH, Wo NC, Chan WY. Manning M, et al. Among authors: cheng ll. J Pept Sci. 1995 Jan-Feb;1(1):66-79. doi: 10.1002/psc.310010109. J Pept Sci. 1995. PMID: 9222985

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