Anlezark GM - Search Results

1

Sensitization of colorectal and pancreatic cancer cell lines to the prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by retroviral transduction and expression of the E. coli nitroreductase gene.

Green NK, Youngs DJ, Neoptolemos JP, Friedlos F, Knox RJ, Springer CJ, Anlezark GM, Michael NP, Melton RG, Ford MJ, Young LS, Kerr DJ, Searle PF. Green NK, et al. Among authors: anlezark gm. Cancer Gene Ther. 1997 Jul-Aug;4(4):229-38. Cancer Gene Ther. 1997. PMID: 9253508

2

The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--I. Purification and properties of a nitroreductase enzyme from Escherichia coli--a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT).

Anlezark GM, Melton RG, Sherwood RF, Coles B, Friedlos F, Knox RJ. Anlezark GM, et al. Biochem Pharmacol. 1992 Dec 15;44(12):2289-95. doi: 10.1016/0006-2952(92)90671-5. Biochem Pharmacol. 1992. PMID: 1472094

3

The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase.

Knox RJ, Friedlos F, Sherwood RF, Melton RG, Anlezark GM. Knox RJ, et al. Among authors: anlezark gm. Biochem Pharmacol. 1992 Dec 15;44(12):2297-301. doi: 10.1016/0006-2952(92)90672-6. Biochem Pharmacol. 1992. PMID: 1472095

4

Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase.

Anlezark GM, Melton RG, Sherwood RF, Wilson WR, Denny WA, Palmer BD, Knox RJ, Friedlos F, Williams A. Anlezark GM, et al. Biochem Pharmacol. 1995 Aug 25;50(5):609-18. doi: 10.1016/0006-2952(95)00187-5. Biochem Pharmacol. 1995. PMID: 7669063

5

Virtual cofactors for an Escherichia coli nitroreductase enzyme: relevance to reductively activated prodrugs in antibody directed enzyme prodrug therapy (ADEPT).

Knox RJ, Friedlos F, Jarman M, Davies LC, Goddard P, Anlezark GM, Melton RG, Sherwood RF. Knox RJ, et al. Among authors: anlezark gm. Biochem Pharmacol. 1995 May 26;49(11):1641-7. doi: 10.1016/0006-2952(95)00077-d. Biochem Pharmacol. 1995. PMID: 7786305

6

Physical characterisation of the Escherichia coli B gene encoding nitroreductase and its over-expression in Escherichia coli K12.

Michael NP, Brehm JK, Anlezark GM, Minton NP. Michael NP, et al. Among authors: anlezark gm. FEMS Microbiol Lett. 1994 Dec 1;124(2):195-202. doi: 10.1111/j.1574-6968.1994.tb07284.x. FEMS Microbiol Lett. 1994. PMID: 7813889

7

Crystallization and preliminary crystallographic data for an FMN-dependent nitroreductase from Escherichia coli B.

Skelly JV, Collins PJ, Knox RJ, Anlezark GM, Melton RG. Skelly JV, et al. Among authors: anlezark gm. J Mol Biol. 1994 May 20;238(5):852-3. doi: 10.1006/jmbi.1994.1340. J Mol Biol. 1994. PMID: 8182754

8

Repeated cycles of Clostridium-directed enzyme prodrug therapy result in sustained antitumour effects in vivo.

Theys J, Pennington O, Dubois L, Anlezark G, Vaughan T, Mengesha A, Landuyt W, Anné J, Burke PJ, Dûrre P, Wouters BG, Minton NP, Lambin P. Theys J, et al. Br J Cancer. 2006 Nov 6;95(9):1212-9. doi: 10.1038/sj.bjc.6603367. Epub 2006 Oct 3. Br J Cancer. 2006. PMID: 17024128 Free PMC article.

9

Bacillus amyloliquefaciens orthologue of Bacillus subtilis ywrO encodes a nitroreductase enzyme which activates the prodrug CB 1954.

Anlezark GM, Vaughan T, Fashola-Stone E, Paul Michael N, Murdoch H, Sims MA, Stubbs S, Wigley S, Minton NP. Anlezark GM, et al. Microbiology (Reading). 2002 Jan;148(Pt 1):297-306. doi: 10.1099/00221287-148-1-297. Microbiology (Reading). 2002. PMID: 11782522 Free article.

10

Dopamine agonists and audiogenic seizures: the relationship between protection against seizures and changes in monoamine metabolism.

Anlezark GM, Horton RW, Meldrum BS. Anlezark GM, et al. Biochem Pharmacol. 1978;27(24):2821-8. doi: 10.1016/0006-2952(78)90196-x. Biochem Pharmacol. 1978. PMID: 581645 No abstract available.

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