Lynas J - Search Results

1

Peptidyl inverse esters of p-methoxybenzoic acid: a novel class of potent inactivator of the serine proteases.

Lynas J, Walker B. Lynas J, et al. Biochem J. 1997 Aug 1;325 ( Pt 3)(Pt 3):609-16. doi: 10.1042/bj3250609. Biochem J. 1997. PMID: 9271079 Free PMC article.

2

Irreversible inhibition of the bacterial cysteine protease-transpeptidase sortase (SrtA) by substrate-derived affinity labels.

Scott CJ, McDowell A, Martin SL, Lynas JF, Vandenbroeck K, Walker B. Scott CJ, et al. Among authors: lynas jf. Biochem J. 2002 Sep 15;366(Pt 3):953-8. doi: 10.1042/BJ20020602. Biochem J. 2002. PMID: 12069686 Free PMC article.

3

Dipeptide proline diphenyl phosphonates are potent, irreversible inhibitors of seprase (FAPalpha).

Gilmore BF, Lynas JF, Scott CJ, McGoohan C, Martin L, Walker B. Gilmore BF, et al. Among authors: lynas jf. Biochem Biophys Res Commun. 2006 Jul 28;346(2):436-46. doi: 10.1016/j.bbrc.2006.05.175. Biochem Biophys Res Commun. 2006. PMID: 16769036

4

Evaluation of dipeptide alpha-keto-beta-aldehydes as new inhibitors of cathepsin S.

Walker B, Lynas JF, Meighan MA, Brömme D. Walker B, et al. Among authors: lynas jf. Biochem Biophys Res Commun. 2000 Aug 28;275(2):401-5. doi: 10.1006/bbrc.2000.3311. Biochem Biophys Res Commun. 2000. PMID: 10964677

5

Strategies for the inhibition of serine proteases.

Walker B, Lynas JF. Walker B, et al. Among authors: lynas jf. Cell Mol Life Sci. 2001 Apr;58(4):596-624. doi: 10.1007/PL00000884. Cell Mol Life Sci. 2001. PMID: 11361094 Free PMC article. Review.

6

Peptides containing acylated C-terminal gem diamines: novel irreversible inactivators of the cysteine and serine proteinases.

Gilmore BF, Lynas JF, Harriott P, Healy A, Walker B. Gilmore BF, et al. Among authors: lynas jf. Chem Biol Drug Des. 2006 May;67(5):364-9. doi: 10.1111/j.1747-0285.2006.00390.x. Chem Biol Drug Des. 2006. PMID: 16784461

7

Inhibitors of the chymotrypsin-like activity of proteasome based on di- and tri-peptidyl alpha-keto aldehydes (glyoxals).

Lynas JF, Harriott P, Healy A, McKervey MA, Walker B. Lynas JF, et al. Bioorg Med Chem Lett. 1998 Feb 17;8(4):373-8. doi: 10.1016/s0960-894x(98)00030-4. Bioorg Med Chem Lett. 1998. PMID: 9871688

8

Solid-phase synthesis and biological screening of N-alpha-mercaptoamide template-based matrix metalloprotease inhibitors.

Lynas JF, Martin SL, Walker B, Baxter AD, Bird J, Bhogal R, Montana JG, Owen DA. Lynas JF, et al. Comb Chem High Throughput Screen. 2000 Feb;3(1):37-41. doi: 10.2174/1386207003327738. Comb Chem High Throughput Screen. 2000. PMID: 10702612

9

Potent new leucine aminopeptidase inhibitor of novel structure synthesised by a modified Wadsworth-Emmons (Horner) Wittig procedure.

Walker B, Darkins PA, McKervey MA, Moncrieff HM, Lynas JF. Walker B, et al. Among authors: lynas jf. Bioorg Med Chem Lett. 2000 Jul 3;10(13):1481-2. doi: 10.1016/s0960-894x(00)00261-4. Bioorg Med Chem Lett. 2000. PMID: 10888337

10

Development of peptidyl alpha-keto-beta-aldehydes as new inhibitors of cathepsin L--comparisons of potency and selectivity profiles with cathepsin B.

Lynas JF, Hawthorne SJ, Walker B. Lynas JF, et al. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1771-3. doi: 10.1016/s0960-894x(00)00340-1. Bioorg Med Chem Lett. 2000. PMID: 10937745

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