Bossard MJ - Search Results

1

Peptide aldehyde inhibitors of cathepsin K inhibit bone resorption both in vitro and in vivo.

Votta BJ, Levy MA, Badger A, Bradbeer J, Dodds RA, James IE, Thompson S, Bossard MJ, Carr T, Connor JR, Tomaszek TA, Szewczuk L, Drake FH, Veber DF, Gowen M. Votta BJ, et al. Among authors: bossard mj. J Bone Miner Res. 1997 Sep;12(9):1396-406. doi: 10.1359/jbmr.1997.12.9.1396. J Bone Miner Res. 1997. PMID: 9286755 Free article.

2

Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification.

Bossard MJ, Tomaszek TA, Thompson SK, Amegadzie BY, Hanning CR, Jones C, Kurdyla JT, McNulty DE, Drake FH, Gowen M, Levy MA. Bossard MJ, et al. J Biol Chem. 1996 May 24;271(21):12517-24. doi: 10.1074/jbc.271.21.12517. J Biol Chem. 1996. PMID: 8647860 Free article.

3

Design of potent and selective human cathepsin K inhibitors that span the active site.

Thompson SK, Halbert SM, Bossard MJ, Tomaszek TA, Levy MA, Zhao B, Smith WW, Abdel-Meguid SS, Janson CA, D'Alessio KJ, McQueney MS, Amegadzie BY, Hanning CR, DesJarlais RL, Briand J, Sarkar SK, Huddleston MJ, Ijames CF, Carr SA, Garnes KT, Shu A, Heys JR, Bradbeer J, Zembryki D, Lee-Rykaczewski L, James IE, Lark MW, Drake FH, Gowen M, Gleason JG, Veber DF. Thompson SK, et al. Among authors: bossard mj. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14249-54. doi: 10.1073/pnas.94.26.14249. Proc Natl Acad Sci U S A. 1997. PMID: 9405598 Free PMC article.

4

Design and synthesis of diaminopyrrolidinone inhibitors of human osteoclast cathepsin K.

Duffy KJ, Ridgers LH, DesJarlais RL, Tomaszek TA, Bossard MJ, Thompson SK, Keenan RM, Veber DF. Duffy KJ, et al. Among authors: bossard mj. Bioorg Med Chem Lett. 1999 Jul 19;9(14):1907-10. doi: 10.1016/s0960-894x(99)00322-4. Bioorg Med Chem Lett. 1999. PMID: 10450951

5

Mechanism of inhibition of cathepsin K by potent, selective 1, 5-diacylcarbohydrazides: a new class of mechanism-based inhibitors of thiol proteases.

Bossard MJ, Tomaszek TA, Levy MA, Ijames CF, Huddleston MJ, Briand J, Thompson S, Halpert S, Veber DF, Carr SA, Meek TD, Tew DG. Bossard MJ, et al. Biochemistry. 1999 Nov 30;38(48):15893-902. doi: 10.1021/bi991193+. Biochemistry. 1999. PMID: 10625455

6

A single Trp121 to Ala121 mutation in human cyclophilin alters cyclosporin A affinity and peptidyl-prolyl isomerase activity.

Bossard MJ, Koser PL, Brandt M, Bergsma DJ, Levy MA. Bossard MJ, et al. Biochem Biophys Res Commun. 1991 May 15;176(3):1142-8. doi: 10.1016/0006-291x(91)90404-u. Biochem Biophys Res Commun. 1991. PMID: 2039499

7

Catalytic and ligand binding properties of the FK506 binding protein FKBP12: effects of the single amino acid substitution of Tyr82 to Leu.

Bossard MJ, Bergsma DJ, Brandt M, Livi GP, Eng WK, Johnson RK, Levy MA. Bossard MJ, et al. Biochem J. 1994 Jan 15;297 ( Pt 2)(Pt 2):365-72. doi: 10.1042/bj2970365. Biochem J. 1994. PMID: 7507662 Free PMC article.

8

The tyrosine89 residue of yeast FKBP12 is required for rapamycin binding.

Koser PL, Eng WK, Bossard MJ, McLaughlin MM, Cafferkey R, Sathe GM, Faucette L, Levy MA, Johnson RK, Bergsma DJ, Livi GP. Koser PL, et al. Among authors: bossard mj. Gene. 1993 Jul 30;129(2):159-65. doi: 10.1016/0378-1119(93)90264-4. Gene. 1993. PMID: 8325502

9

The yeast cyclophilin multigene family: purification, cloning and characterization of a new isoform.

McLaughlin MM, Bossard MJ, Koser PL, Cafferkey R, Morris RA, Miles LM, Strickler J, Bergsma DJ, Levy MA, Livi GP. McLaughlin MM, et al. Among authors: bossard mj. Gene. 1992 Feb 1;111(1):85-92. doi: 10.1016/0378-1119(92)90606-p. Gene. 1992. PMID: 1547957

10

The CYP2 gene of Saccharomyces cerevisiae encodes a cyclosporin A-sensitive peptidyl-prolyl cis-trans isomerase with an N-terminal signal sequence.

Koser PL, Bergsma DJ, Cafferkey R, Eng WK, McLaughlin MM, Ferrara A, Silverman C, Kasyan K, Bossard MJ, Johnson RK, Porterd TG, Levy MA, Livi GP. Koser PL, et al. Among authors: bossard mj. Gene. 1991 Dec 1;108(1):73-80. doi: 10.1016/0378-1119(91)90489-x. Gene. 1991. PMID: 1761234

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