He K - Search Results

1

Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins.

Schmiedlin-Ren P, Edwards DJ, Fitzsimmons ME, He K, Lown KS, Woster PM, Rahman A, Thummel KE, Fisher JM, Hollenberg PF, Watkins PB. Schmiedlin-Ren P, et al. Among authors: he k. Drug Metab Dispos. 1997 Nov;25(11):1228-33. Drug Metab Dispos. 1997. PMID: 9351897

2

Inactivation of cytochrome P450 3A4 by bergamottin, a component of grapefruit juice.

He K, Iyer KR, Hayes RN, Sinz MW, Woolf TF, Hollenberg PF. He K, et al. Chem Res Toxicol. 1998 Apr;11(4):252-9. doi: 10.1021/tx970192k. Chem Res Toxicol. 1998. PMID: 9548795

3

Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486).

He K, Woolf TF, Hollenberg PF. He K, et al. J Pharmacol Exp Ther. 1999 Feb;288(2):791-7. J Pharmacol Exp Ther. 1999. PMID: 9918590

4

Bergamottin contribution to the grapefruit juice-felodipine interaction and disposition in humans.

Goosen TC, Cillié D, Bailey DG, Yu C, He K, Hollenberg PF, Woster PM, Cohen L, Williams JA, Rheeders M, Dijkstra HP. Goosen TC, et al. Among authors: he k. Clin Pharmacol Ther. 2004 Dec;76(6):607-17. doi: 10.1016/j.clpt.2004.08.019. Clin Pharmacol Ther. 2004. PMID: 15592332 Free article. Clinical Trial.

5

Identification of the heme adduct and an active site peptide modified during mechanism-based inactivation of rat liver cytochrome P450 2B1 by secobarbital.

He K, Falick AM, Chen B, Nilsson F, Correia MA. He K, et al. Chem Res Toxicol. 1996 Apr-May;9(3):614-22. doi: 10.1021/tx950177k. Chem Res Toxicol. 1996. PMID: 8728507

6

Secobarbital-mediated inactivation of cytochrome P450 2B1 and its active site mutants. Partitioning between heme and protein alkylation and epoxidation.

He K, He YA, Szklarz GD, Halpert JR, Correia MA. He K, et al. Among authors: he ya. J Biol Chem. 1996 Oct 18;271(42):25864-72. doi: 10.1074/jbc.271.42.25864. J Biol Chem. 1996. PMID: 8824218 Free article.

7

Troglitazone quinone formation catalyzed by human and rat CYP3A: an atypical CYP oxidation reaction.

He K, Woolf TF, Kindt EK, Fielder AE, Talaat RE. He K, et al. Biochem Pharmacol. 2001 Jul 15;62(2):191-8. doi: 10.1016/s0006-2952(01)00653-0. Biochem Pharmacol. 2001. PMID: 11389877

8

Cytochrome P450 2C11: Escherichia coli expression, purification, functional characterization, and mechanism-based inactivation of the enzyme.

Licad-Coles E, He K, Yin H, Correia MA. Licad-Coles E, et al. Among authors: he k. Arch Biochem Biophys. 1997 Feb 1;338(1):35-42. doi: 10.1006/abbi.1996.9795. Arch Biochem Biophys. 1997. PMID: 9015385

9

The induction of liver microsomal cytochrome P450 by Glycyrrhiza uralensis and glycyrrhetinic acid in mice.

Hu WY, Li YW, Hou YN, He K, Chen JF, But PP, Zhu XY. Hu WY, et al. Among authors: he k. Biomed Environ Sci. 1999 Mar;12(1):10-4. Biomed Environ Sci. 1999. PMID: 10442216

10

Identification of the heme-modified peptides from cumene hydroperoxide-inactivated cytochrome P450 3A4.

He K, Bornheim LM, Falick AM, Maltby D, Yin H, Correia MA. He K, et al. Biochemistry. 1998 Dec 15;37(50):17448-57. doi: 10.1021/bi9808464. Biochemistry. 1998. PMID: 9860860

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