Kornbrust DJ - Search Results

1

Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide, in a 4-week study in CD-1 mice.

Henry SP, Taylor J, Midgley L, Levin AA, Kornbrust DJ. Henry SP, et al. Among authors: kornbrust dj. Antisense Nucleic Acid Drug Dev. 1997 Oct;7(5):473-81. doi: 10.1089/oli.1.1997.7.473. Antisense Nucleic Acid Drug Dev. 1997. PMID: 9361906

2

Activation of the alternative pathway of complement by a phosphorothioate oligonucleotide: potential mechanism of action.

Henry SP, Giclas PC, Leeds J, Pangburn M, Auletta C, Levin AA, Kornbrust DJ. Henry SP, et al. Among authors: kornbrust dj. J Pharmacol Exp Ther. 1997 May;281(2):810-6. J Pharmacol Exp Ther. 1997. PMID: 9152389

3

Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide, in a four-week study in cynomolgus monkeys.

Henry SP, Bolte H, Auletta C, Kornbrust DJ. Henry SP, et al. Among authors: kornbrust dj. Toxicology. 1997 Jun 27;120(2):145-55. doi: 10.1016/s0300-483x(97)03661-5. Toxicology. 1997. PMID: 9184201

4

Inhibition of coagulation by a phosphorothioate oligonucleotide.

Henry SP, Novotny W, Leeds J, Auletta C, Kornbrust DJ. Henry SP, et al. Among authors: kornbrust dj. Antisense Nucleic Acid Drug Dev. 1997 Oct;7(5):503-10. doi: 10.1089/oli.1.1997.7.503. Antisense Nucleic Acid Drug Dev. 1997. PMID: 9361909

5

Comparison of the toxicity profiles of ISIS 1082 and ISIS 2105, phosphorothioate oligonucleotides, following subacute intradermal administration in Sprague-Dawley rats.

Henry SP, Grillone LR, Orr JL, Bruner RH, Kornbrust DJ. Henry SP, et al. Among authors: kornbrust dj. Toxicology. 1997 Jan 15;116(1-3):77-88. doi: 10.1016/s0300-483x(96)03532-9. Toxicology. 1997. PMID: 9020509

6

Pharmacokinetics of a potential human cytomegalovirus therapeutic, a phosphorothioate oligonucleotide, after intravitreal injection in the rabbit.

Leeds JM, Henry SP, Truong L, Zutshi A, Levin AA, Kornbrust D. Leeds JM, et al. Drug Metab Dispos. 1997 Aug;25(8):921-6. Drug Metab Dispos. 1997. PMID: 9280399

7

An ICAM-1 antisense oligonucleotide prevents and reverses dextran sulfate sodium-induced colitis in mice.

Bennett CF, Kornbrust D, Henry S, Stecker K, Howard R, Cooper S, Dutson S, Hall W, Jacoby HI. Bennett CF, et al. J Pharmacol Exp Ther. 1997 Feb;280(2):988-1000. J Pharmacol Exp Ther. 1997. PMID: 9023316

8

Toxicity and toxicokinetics of a phosphorothioate oligonucleotide against the c-myc oncogene in cynomolgus monkeys.

Webb MS, Tortora N, Cremese M, Kozlowska H, Blaquiere M, Devine DV, Kornbrust DJ. Webb MS, et al. Among authors: kornbrust dj. Antisense Nucleic Acid Drug Dev. 2001 Jun;11(3):155-63. doi: 10.1089/108729001300338681. Antisense Nucleic Acid Drug Dev. 2001. PMID: 11446591

9

The Oligonucleotide Safety Working Group (OSWG).

Schubert D, Levin AA, Kornbrust D, Berman CL, Cavagnaro J, Henry S, Seguin R, Ferrari N, Shrewsbury SB. Schubert D, et al. Nucleic Acid Ther. 2012 Aug;22(4):211-2. doi: 10.1089/nat.2012.0383. Nucleic Acid Ther. 2012. PMID: 22913593 No abstract available.

10

Considerations for assessment of reproductive and developmental toxicity of oligonucleotide-based therapeutics.

Cavagnaro J, Berman C, Kornbrust D, White T, Campion S, Henry S. Cavagnaro J, et al. Nucleic Acid Ther. 2014 Oct;24(5):313-25. doi: 10.1089/nat.2014.0490. Epub 2014 Aug 19. Nucleic Acid Ther. 2014. PMID: 25137397 Review.

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