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Page 1
4-hydroxy-5,6-dihydropyrones. 2. Potent non-peptide inhibitors of HIV protease.
Tait BD, Hagen S, Domagala J, Ellsworth EL, Gajda C, Hamilton HW, Prasad JV, Ferguson D, Graham N, Hupe D, Nouhan C, Tummino PJ, Humblet C, Lunney EA, Pavlovsky A, Rubin J, Gracheck SJ, Baldwin ET, Bhat TN, Erickson JW, Gulnik SV, Liu B. Tait BD, et al. Among authors: pavlovsky a. J Med Chem. 1997 Nov 7;40(23):3781-92. doi: 10.1021/jm970615f. J Med Chem. 1997. PMID: 9371244
Nonpeptidic HIV protease inhibitors possessing excellent antiviral activities and therapeutic indices. PD 178390: a lead HIV protease inhibitor.
Prasad JV, Boyer FE, Domagala JM, Ellsworth EL, Gajda C, Hamilton HW, Hagen SE, Markoski LJ, Steinbaugh BA, Tait BD, Humblet C, Lunney EA, Pavlovsky A, Rubin JR, Ferguson D, Graham N, Holler T, Hupe D, Nouhan C, Tummino PJ, Urumov A, Zeikus E, Zeikus G, Gracheck SJ, Erickson JW, et al. Prasad JV, et al. Among authors: pavlovsky a. Bioorg Med Chem. 1999 Dec;7(12):2775-800. doi: 10.1016/s0968-0896(99)00215-1. Bioorg Med Chem. 1999. PMID: 10658583
4-Hydroxy-5,6-dihydropyrones as inhibitors of HIV protease: the effect of heterocyclic substituents at C-6 on antiviral potency and pharmacokinetic parameters.
Hagen SE, Domagala J, Gajda C, Lovdahl M, Tait BD, Wise E, Holler T, Hupe D, Nouhan C, Urumov A, Zeikus G, Zeikus E, Lunney EA, Pavlovsky A, Gracheck SJ, Saunders J, VanderRoest S, Brodfuehrer J. Hagen SE, et al. Among authors: pavlovsky a. J Med Chem. 2001 Jul 5;44(14):2319-32. doi: 10.1021/jm0003844. J Med Chem. 2001. PMID: 11428926
Discovery and optimization of nonpeptide HIV-1 protease inhibitors.
Tummino PJ, Prasad JV, Ferguson D, Nouhan C, Graham N, Domagala JM, Ellsworth E, Gajda C, Hagen SE, Lunney EA, Para KS, Tait BD, Pavlovsky A, Erickson JW, Gracheck S, McQuade TJ, Hupe DJ. Tummino PJ, et al. Among authors: pavlovsky a. Bioorg Med Chem. 1996 Sep;4(9):1401-10. doi: 10.1016/0968-0896(96)00134-4. Bioorg Med Chem. 1996. PMID: 8894098
Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia.
Pfefferkorn JA, Choi C, Larsen SD, Auerbach B, Hutchings R, Park W, Askew V, Dillon L, Hanselman JC, Lin Z, Lu GH, Robertson A, Sekerke C, Harris MS, Pavlovsky A, Bainbridge G, Caspers N, Kowala M, Tait BD. Pfefferkorn JA, et al. Among authors: pavlovsky a. J Med Chem. 2008 Jan 10;51(1):31-45. doi: 10.1021/jm070849r. Epub 2007 Dec 12. J Med Chem. 2008. PMID: 18072721
308 results