Cathepsin B activity regulation. Heparin-like glycosaminogylcans protect human cathepsin B from alkaline pH-induced inactivation.
Almeida PC, Nantes IL, Chagas JR, Rizzi CC, Faljoni-Alario A, Carmona E, Juliano L, Nader HB, Tersariol IL.
Almeida PC, et al. Among authors: juliano l.
J Biol Chem. 2001 Jan 12;276(2):944-51. doi: 10.1074/jbc.M003820200.
J Biol Chem. 2001.
PMID: 11016923
Free article.
Recently, we have shown that heparin and heparan sulfate bind to papain specifically; this interaction induces an increase of its alpha-helix content and stabilizes the enzyme structure even at alkaline pH (Almeida, P. C., Nantes, I. L., Rizzi, C. C. A., Judice, W. A. S., …
Recently, we have shown that heparin and heparan sulfate bind to papain specifically; this interaction induces an increase of its alpha-heli …