McDowell RS - Search Results

1

Inhibition of HIV type 1 infectivity by constrained alpha-helical peptides: implications for the viral fusion mechanism.

Judice JK, Tom JY, Huang W, Wrin T, Vennari J, Petropoulos CJ, McDowell RS. Judice JK, et al. Among authors: mcdowell rs. Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13426-30. doi: 10.1073/pnas.94.25.13426. Proc Natl Acad Sci U S A. 1997. PMID: 9391041 Free PMC article.

2

Growth hormone secretagogues: characterization, efficacy, and minimal bioactive conformation.

McDowell RS, Elias KA, Stanley MS, Burdick DJ, Burnier JP, Chan KS, Fairbrother WJ, Hammonds RG, Ingle GS, Jacobsen NE, Mortensen DL, Rawson TE, Won WB, Clark RG, Somers TC. McDowell RS, et al. Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11165-9. doi: 10.1073/pnas.92.24.11165. Proc Natl Acad Sci U S A. 1995. PMID: 7479958 Free PMC article.

3

Binding of small molecules to an adaptive protein-protein interface.

Arkin MR, Randal M, DeLano WL, Hyde J, Luong TN, Oslob JD, Raphael DR, Taylor L, Wang J, McDowell RS, Wells JA, Braisted AC. Arkin MR, et al. Among authors: mcdowell rs. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1603-8. doi: 10.1073/pnas.252756299. Epub 2003 Feb 11. Proc Natl Acad Sci U S A. 2003. PMID: 12582206 Free PMC article.

4

Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding.

Romanowski MJ, Scheer JM, O'Brien T, McDowell RS. Romanowski MJ, et al. Among authors: mcdowell rs. Structure. 2004 Aug;12(8):1361-71. doi: 10.1016/j.str.2004.05.010. Structure. 2004. PMID: 15296730 Free article.

5

Model peptide studies demonstrate that amphipathic secondary structures can be recognized by the chaperonin GroEL (cpn60).

Brazil BT, Cleland JL, McDowell RS, Skelton NJ, Paris K, Horowitz PM. Brazil BT, et al. Among authors: mcdowell rs. J Biol Chem. 1997 Feb 21;272(8):5105-11. doi: 10.1074/jbc.272.8.5105. J Biol Chem. 1997. PMID: 9030576 Free article.

6

A minimal peptide scaffold for beta-turn display: optimizing a strand position in disulfide-cyclized beta-hairpins.

Cochran AG, Tong RT, Starovasnik MA, Park EJ, McDowell RS, Theaker JE, Skelton NJ. Cochran AG, et al. Among authors: mcdowell rs. J Am Chem Soc. 2001 Jan 31;123(4):625-32. doi: 10.1021/ja003369x. J Am Chem Soc. 2001. PMID: 11456574

7

Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1.

Yang W, Lu W, Lu Y, Zhong M, Sun J, Thomas AE, Wilkinson JM, Fucini RV, Lam M, Randal M, Shi XP, Jacobs JW, McDowell RS, Gordon EM, Ballinger MD. Yang W, et al. Among authors: mcdowell rs. J Med Chem. 2006 Feb 9;49(3):839-42. doi: 10.1021/jm0509142. J Med Chem. 2006. PMID: 16451048

8

Benzodiazepine peptidomimetic inhibitors of farnesyltransferase.

Marsters JC Jr, McDowell RS, Reynolds ME, Oare DA, Somers TC, Stanley MS, Rawson TE, Struble ME, Burdick DJ, Chan KS, et al. Marsters JC Jr, et al. Among authors: mcdowell rs. Bioorg Med Chem. 1994 Sep;2(9):949-57. doi: 10.1016/s0968-0896(00)82044-1. Bioorg Med Chem. 1994. PMID: 7712130

9

Fragment-based drug discovery.

Erlanson DA, McDowell RS, O'Brien T. Erlanson DA, et al. Among authors: mcdowell rs. J Med Chem. 2004 Jul 1;47(14):3463-82. doi: 10.1021/jm040031v. J Med Chem. 2004. PMID: 15214773 Review. No abstract available.

10

From peptide to non-peptide. 3. Atropisomeric GPIIbIIIa antagonists containing the 3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione nucleus.

Blackburn BK, Lee A, Baier M, Kohl B, Olivero AG, Matamoros R, Robarge KD, McDowell RS. Blackburn BK, et al. Among authors: mcdowell rs. J Med Chem. 1997 Feb 28;40(5):717-29. doi: 10.1021/jm960652r. J Med Chem. 1997. PMID: 9057858

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