Gros P - Search Results

1

Binding of steroid modulators to recombinant cytosolic domain from mouse P-glycoprotein in close proximity to the ATP site.

Dayan G, Jault JM, Baubichon-Cortay H, Baggetto LG, Renoir JM, Baulieu EE, Gros P, Di Pietro A. Dayan G, et al. Among authors: gros p. Biochemistry. 1997 Dec 9;36(49):15208-15. doi: 10.1021/bi9718696. Biochemistry. 1997. PMID: 9398248

2

Conformational change induced by ATP binding in the multidrug ATP-binding cassette transporter BmrA.

Orelle C, Gubellini F, Durand A, Marco S, Lévy D, Gros P, Di Pietro A, Jault JM. Orelle C, et al. Among authors: gros p. Biochemistry. 2008 Feb 26;47(8):2404-12. doi: 10.1021/bi702303s. Epub 2008 Jan 24. Biochemistry. 2008. PMID: 18215075

3

The conserved glutamate residue adjacent to the Walker-B motif is the catalytic base for ATP hydrolysis in the ATP-binding cassette transporter BmrA.

Orelle C, Dalmas O, Gros P, Di Pietro A, Jault JM. Orelle C, et al. Among authors: gros p. J Biol Chem. 2003 Nov 21;278(47):47002-8. doi: 10.1074/jbc.M308268200. Epub 2003 Sep 10. J Biol Chem. 2003. PMID: 12968023 Free article.

4

Analysis of catalytic carboxylate mutants E552Q and E1197Q suggests asymmetric ATP hydrolysis by the two nucleotide-binding domains of P-glycoprotein.

Carrier I, Julien M, Gros P. Carrier I, et al. Among authors: gros p. Biochemistry. 2003 Nov 11;42(44):12875-85. doi: 10.1021/bi034257w. Biochemistry. 2003. PMID: 14596601

5

Mutations in either nucleotide-binding site of P-glycoprotein (Mdr3) prevent vanadate trapping of nucleotide at both sites.

Urbatsch IL, Beaudet L, Carrier I, Gros P. Urbatsch IL, et al. Among authors: gros p. Biochemistry. 1998 Mar 31;37(13):4592-602. doi: 10.1021/bi9728001. Biochemistry. 1998. PMID: 9521779

6

Mutations in the nucleotide-binding sites of P-glycoprotein that affect substrate specificity modulate substrate-induced adenosine triphosphatase activity.

Beaudet L, Urbatsch IL, Gros P. Beaudet L, et al. Among authors: gros p. Biochemistry. 1998 Jun 23;37(25):9073-82. doi: 10.1021/bi972656j. Biochemistry. 1998. PMID: 9636053

Within this segment, we identified two sets of residues [ERGA --> DKGT (522-525) and T578C] that, when replaced by their NBD2 counterparts, cause dramatic alterations of the substrate specificity of the protein [Beaudet, L., and Gros, P. (1995) J. Biol. Chem. 270 …

Within this segment, we identified two sets of residues [ERGA --> DKGT (522-525) and T578C] that, when replaced by their NBD2 counterpart …

7

Nucleotide-induced conformational changes in P-glycoprotein and in nucleotide binding site mutants monitored by trypsin sensitivity.

Julien M, Gros P. Julien M, et al. Among authors: gros p. Biochemistry. 2000 Apr 18;39(15):4559-68. doi: 10.1021/bi992744z. Biochemistry. 2000. PMID: 10758006

8

Functional analysis of P-glycoprotein mutants identifies predicted transmembrane domain 11 as a putative drug binding site.

Kajiji S, Talbot F, Grizzuti K, Van Dyke-Phillips V, Agresti M, Safa AR, Gros P. Kajiji S, et al. Among authors: gros p. Biochemistry. 1993 Apr 27;32(16):4185-94. doi: 10.1021/bi00067a005. Biochemistry. 1993. PMID: 7682843

9

Membrane topology of P-glycoprotein as determined by epitope insertion: transmembrane organization of the N-terminal domain of mdr3.

Kast C, Canfield V, Levenson R, Gros P. Kast C, et al. Among authors: gros p. Biochemistry. 1995 Apr 4;34(13):4402-11. doi: 10.1021/bi00013a032. Biochemistry. 1995. PMID: 7535563

10

Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators.

Tang-Wai DF, Kajiji S, DiCapua F, de Graaf D, Roninson IB, Gros P. Tang-Wai DF, et al. Among authors: gros p. Biochemistry. 1995 Jan 10;34(1):32-9. doi: 10.1021/bi00001a005. Biochemistry. 1995. PMID: 7819214

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