Van der Graaf PH - Search Results

1

On the reliability of affinity and efficacy estimates obtained by direct operational model fitting of agonist concentration-effect curves following irreversible receptor inactivation.

Van der Graaf PH, Danhof M. Van der Graaf PH, et al. J Pharmacol Toxicol Methods. 1997 Oct;38(2):81-5. doi: 10.1016/s1056-8719(97)00052-x. J Pharmacol Toxicol Methods. 1997. PMID: 9403778

2

Analysis of the action of idazoxan calls into question the reliability of the rat isolated small mesenteric artery assay as a predictor for alpha 1-adrenoceptor-mediated pressor activity.

Van der Graaf PH, Shankley NP, Black JW. Van der Graaf PH, et al. Naunyn Schmiedebergs Arch Pharmacol. 1996 Aug-Sep;354(3):389-92. doi: 10.1007/BF00171074. Naunyn Schmiedebergs Arch Pharmacol. 1996. PMID: 8878073

3

Analysis of drug-receptor interactions in vivo: a new approach in pharmacokinetic-pharmacodynamic modelling.

Van der Graaf PH, Danhof M. Van der Graaf PH, et al. Int J Clin Pharmacol Ther. 1997 Oct;35(10):442-6. Int J Clin Pharmacol Ther. 1997. PMID: 9352393 Review.

4

Mechanism-based pharmacokinetic-pharmacodynamic modeling of the effects of N6-cyclopentyladenosine analogs on heart rate in rat: estimation of in vivo operational affinity and efficacy at adenosine A1 receptors.

Van Der Graaf PH, Van Schaick EA, Math-ot RA, Ijzerman AP, Danhof M. Van Der Graaf PH, et al. Among authors: van schaick ea. J Pharmacol Exp Ther. 1997 Nov;283(2):809-16. J Pharmacol Exp Ther. 1997. PMID: 9353402

5

Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of synthetic opioids in the rat: correlation with the interaction at the mu-opioid receptor.

Cox EH, Kerbusch T, Van der Graaf PH, Danhof M. Cox EH, et al. Among authors: van der graaf ph. J Pharmacol Exp Ther. 1998 Mar;284(3):1095-103. J Pharmacol Exp Ther. 1998. PMID: 9495871

6

Multivariate quantitative structure-pharmacokinetic relationships (QSPKR) analysis of adenosine A1 receptor agonists in rat.

Van der Graaf PH, Nilsson J, Van Schaick EA, Danhof M. Van der Graaf PH, et al. Among authors: van schaick ea. J Pharm Sci. 1999 Mar;88(3):306-12. doi: 10.1021/js980294a. J Pharm Sci. 1999. PMID: 10052988

7

Mechanism-based pharmacokinetic-pharmacodynamic modeling of antilipolytic effects of adenosine A(1) receptor agonists in rats: prediction of tissue-dependent efficacy in vivo.

Van der Graaf PH, Van Schaick EA, Visser SA, De Greef HJ, Ijzerman AP, Danhof M. Van der Graaf PH, et al. Among authors: van schaick ea. J Pharmacol Exp Ther. 1999 Aug;290(2):702-9. J Pharmacol Exp Ther. 1999. PMID: 10411581

8

Estimation of agonist affinity, using the slope of the concentration-effect curve: comment on the method of Calderone and Martinotti.

Van der Graaf PH. Van der Graaf PH. J Pharmacol Toxicol Methods. 1998 Nov;40(4):241-3. doi: 10.1016/s1056-8719(99)00011-8. J Pharmacol Toxicol Methods. 1998. PMID: 10465160

9

Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy.

Cleton A, Van der Graaf PH, Ghijsen W, Voskuyl R, Danhof M. Cleton A, et al. Among authors: van der graaf ph. Pharm Res. 1999 Nov;16(11):1702-9. doi: 10.1023/a:1018949914532. Pharm Res. 1999. PMID: 10571275

10

Analysis of asymmetry of agonist concentration-effect curves.

Van der Graaf PH, Schoemaker RC. Van der Graaf PH, et al. J Pharmacol Toxicol Methods. 1999 Apr-Jun;41(2-3):107-15. doi: 10.1016/s1056-8719(99)00026-x. J Pharmacol Toxicol Methods. 1999. PMID: 10598682

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