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Tumor necrosis factor alpha (TNF alpha) is cardiodepressant in pathophysiologically relevant concentrations without inducing inducible nitric oxide-(NO)-synthase (iNOS) or triggering serious cytotoxicity.
Müller-Werdan U, Schumann H, Fuchs R, Reithmann C, Loppnow H, Koch S, Zimny-Arndt U, He C, Darmer D, Jungblut P, Stadler J, Holtz J, Werdan K. Müller-Werdan U, et al. Among authors: loppnow h. J Mol Cell Cardiol. 1997 Nov;29(11):2915-23. doi: 10.1006/jmcc.1997.0526. J Mol Cell Cardiol. 1997. PMID: 9405166
Statins potently reduce the cytokine-mediated IL-6 release in SMC/MNC cocultures.
Loppnow H, Zhang L, Buerke M, Lautenschläger M, Chen L, Frister A, Schlitt A, Luther T, Song N, Hofmann B, Rose-John S, Silber RE, Müller-Werdan U, Werdan K. Loppnow H, et al. J Cell Mol Med. 2011 Apr;15(4):994-1004. doi: 10.1111/j.1582-4934.2010.01036.x. J Cell Mol Med. 2011. PMID: 20158569 Free PMC article. Clinical Trial.
Septic cardiomyopathy - A not yet discovered cardiomyopathy?
Muller-Werdan U, Buerke M, Ebelt H, Heinroth KM, Herklotz A, Loppnow H, Ruß M, Schlegel F, Schlitt A, Schmidt HB, Söffker G, Werdan K. Muller-Werdan U, et al. Among authors: loppnow h. Exp Clin Cardiol. 2006 Fall;11(3):226-36. Exp Clin Cardiol. 2006. PMID: 18651035 Free PMC article.
Interleukin-1 potently contributes to 25-hydroxycholesterol-induced synergistic cytokine production in smooth muscle cell-monocyte interactions.
Fu H, Spieler F, Großmann J, Riemann D, Larisch M, Hiebl B, Schlecht K, Jaschke C, Bartling B, Hofmann B, Unverzagt S, Koch S, Pilowski C, Simm A, Silber RE, Gielen S, Seliger B, Schlitt A, Ebelt H, Müller-Werdan U, Buerke M, Werdan K, Loppnow H. Fu H, et al. Among authors: loppnow h. Atherosclerosis. 2014 Dec;237(2):443-52. doi: 10.1016/j.atherosclerosis.2014.10.002. Epub 2014 Oct 5. Atherosclerosis. 2014. PMID: 25463072
99 results