Norbeck DW - Search Results

1

Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacy.

Kempf DJ, Sham HL, Marsh KC, Flentge CA, Betebenner D, Green BE, McDonald E, Vasavanonda S, Saldivar A, Wideburg NE, Kati WM, Ruiz L, Zhao C, Fino L, Patterson J, Molla A, Plattner JJ, Norbeck DW. Kempf DJ, et al. Among authors: norbeck dw. J Med Chem. 1998 Feb 12;41(4):602-17. doi: 10.1021/jm970636+. J Med Chem. 1998. PMID: 9484509

2

Synthesis and structure-activity relationships of a novel series of HIV-1 protease inhibitors encompassing ABT-378 (Lopinavir).

Sham HL, Betebenner DA, Chen X, Saldivar A, Vasavanonda S, Kempf DJ, Plattner JJ, Norbeck DW. Sham HL, et al. Among authors: norbeck dw. Bioorg Med Chem Lett. 2002 Apr 22;12(8):1185-7. doi: 10.1016/s0960-894x(02)00134-8. Bioorg Med Chem Lett. 2002. PMID: 11934584

3

X-ray crystallographic structure of ABT-378 (lopinavir) bound to HIV-1 protease.

Stoll V, Qin W, Stewart KD, Jakob C, Park C, Walter K, Simmer RL, Helfrich R, Bussiere D, Kao J, Kempf D, Sham HL, Norbeck DW. Stoll V, et al. Among authors: norbeck dw. Bioorg Med Chem. 2002 Aug;10(8):2803-6. doi: 10.1016/s0968-0896(02)00051-2. Bioorg Med Chem. 2002. PMID: 12057670

4

Novel lopinavir analogues incorporating non-Aromatic P-1 side chains--synthesis and structure--activity relationships.

Sham HL, Zhao C, Li L, Betebenner DA, Saldivar A, Vasavanonda S, Kempf DJ, Plattner JJ, Norbeck DW. Sham HL, et al. Among authors: norbeck dw. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3101-3. doi: 10.1016/s0960-894x(02)00643-1. Bioorg Med Chem Lett. 2002. PMID: 12372511

5

Synthesis and SAR studies of potent HIV protease inhibitors containing novel dimethylphenoxyl acetates as P2 ligands.

Chen X, Kempf DJ, Li L, Sham HL, Vasavanonda S, Wideburg NE, Saldivar A, Marsh KC, McDonald E, Norbeck DW. Chen X, et al. Among authors: norbeck dw. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3657-60. doi: 10.1016/j.bmcl.2003.08.043. Bioorg Med Chem Lett. 2003. PMID: 14552751

6

Novel lopinavir analogues incorporating heterocyclic replacements of six-member cyclic urea--synthesis and structure-activity relationships.

Sham HL, Betebenner DA, Rosenbrook W, Herrin T, Saldivar A, Vasavanonda S, Plattner JJ, Norbeck DW. Sham HL, et al. Among authors: norbeck dw. Bioorg Med Chem Lett. 2004 May 17;14(10):2643-5. doi: 10.1016/j.bmcl.2004.02.089. Bioorg Med Chem Lett. 2004. PMID: 15109669

7

Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains.

Zhao C, Sham HL, Sun M, Stoll VS, Stewart KD, Lin S, Mo H, Vasavanonda S, Saldivar A, Park C, McDonald EJ, Marsh KC, Klein LL, Kempf DJ, Norbeck DW. Zhao C, et al. Among authors: norbeck dw. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5499-503. doi: 10.1016/j.bmcl.2005.08.093. Epub 2005 Oct 3. Bioorg Med Chem Lett. 2005. PMID: 16203141

8

Potent HIV-1 protease inhibitors with antiviral activities in vitro.

Sham HL, Betebenner DA, Wideburg NE, Saldivar AC, Kohlbrenner WE, Vasavanonda S, Kempf DJ, Norbeck DW, Zhao C, Clement JJ, et al. Sham HL, et al. Among authors: norbeck dw. Biochem Biophys Res Commun. 1991 Mar 29;175(3):914-9. doi: 10.1016/0006-291x(91)91652-s. Biochem Biophys Res Commun. 1991. PMID: 2025263

9

Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease.

Erickson J, Neidhart DJ, VanDrie J, Kempf DJ, Wang XC, Norbeck DW, Plattner JJ, Rittenhouse JW, Turon M, Wideburg N, et al. Erickson J, et al. Among authors: norbeck dw. Science. 1990 Aug 3;249(4968):527-33. doi: 10.1126/science.2200122. Science. 1990. PMID: 2200122

10

Structure-based, C2 symmetric inhibitors of HIV protease.

Kempf DJ, Norbeck DW, Codacovi L, Wang XC, Kohlbrenner WE, Wideburg NE, Paul DA, Knigge MF, Vasavanonda S, Craig-Kennard A, et al. Kempf DJ, et al. Among authors: norbeck dw. J Med Chem. 1990 Oct;33(10):2687-9. doi: 10.1021/jm00172a002. J Med Chem. 1990. PMID: 2213822 No abstract available.

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