Tew DG - Search Results

1

Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor.

Rice SQ, Southan C, Boyd HF, Terrett JA, MacPhee CH, Moores K, Gloger IS, Tew DG. Rice SQ, et al. Among authors: tew dg. Biochem J. 1998 Mar 15;330 ( Pt 3)(Pt 3):1309-15. doi: 10.1042/bj3301309. Biochem J. 1998. PMID: 9494101 Free PMC article.

2

Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor.

MacPhee CH, Moores KE, Boyd HF, Dhanak D, Ife RJ, Leach CA, Leake DS, Milliner KJ, Patterson RA, Suckling KE, Tew DG, Hickey DM. MacPhee CH, et al. Among authors: tew dg. Biochem J. 1999 Mar 1;338 ( Pt 2)(Pt 2):479-87. Biochem J. 1999. PMID: 10024526 Free PMC article.

3

The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076.

Pearce NJ, Yates JW, Berkhout TA, Jackson B, Tew D, Boyd H, Camilleri P, Sweeney P, Gribble AD, Shaw A, Groot PH. Pearce NJ, et al. Biochem J. 1998 Aug 15;334 ( Pt 1)(Pt 1):113-9. doi: 10.1042/bj3340113. Biochem J. 1998. PMID: 9693110 Free PMC article.

4

Mechanism of inhibition of LDL phospholipase A2 by monocyclic-beta-lactams. Burst kinetics and the effect of stereochemistry.

Tew DG, Boyd HF, Ashman S, Theobald C, Leach CA. Tew DG, et al. Biochemistry. 1998 Jul 14;37(28):10087-93. doi: 10.1021/bi9801412. Biochemistry. 1998. PMID: 9665713

5

2-(Alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A2.

Boyd HF, Flynn ST, Hickey DM, Ife RJ, Jones M, Leach CA, Macphee CH, Milliner KJ, Rawlings DA, Slingsby BP, Smith SA, Stansfield IG, Tew DG, Theobald CJ. Boyd HF, et al. Among authors: tew dg. Bioorg Med Chem Lett. 2000 Feb 21;10(4):395-8. doi: 10.1016/s0960-894x(00)00002-0. Bioorg Med Chem Lett. 2000. PMID: 10714508

6

N-1 substituted pyrimidin-4-ones: novel, orally active inhibitors of lipoprotein-associated phospholipase A2.

Boyd HF, Fell SC, Flynn ST, Hickey DM, Ife RJ, Leach CA, Macphee CH, Milliner KJ, Moores KE, Pinto IL, Porter RA, Rawlings DA, Smith SA, Stansfield IG, Tew DG, Theobald CJ, Whittaker CM. Boyd HF, et al. Among authors: tew dg. Bioorg Med Chem Lett. 2000 Nov 20;10(22):2557-61. doi: 10.1016/s0960-894x(00)00510-2. Bioorg Med Chem Lett. 2000. PMID: 11086729

7

Purification, properties, sequencing, and cloning of a lipoprotein-associated, serine-dependent phospholipase involved in the oxidative modification of low-density lipoproteins.

Tew DG, Southan C, Rice SQ, Lawrence MP, Li H, Boyd HF, Moores K, Gloger IS, Macphee CH. Tew DG, et al. Arterioscler Thromb Vasc Biol. 1996 Apr;16(4):591-9. doi: 10.1161/01.atv.16.4.591. Arterioscler Thromb Vasc Biol. 1996. PMID: 8624782

8

Identification of a novel aspartic protease (Asp 2) as beta-secretase.

Hussain I, Powell D, Howlett DR, Tew DG, Meek TD, Chapman C, Gloger IS, Murphy KE, Southan CD, Ryan DM, Smith TS, Simmons DL, Walsh FS, Dingwall C, Christie G. Hussain I, et al. Among authors: tew dg. Mol Cell Neurosci. 1999 Dec;14(6):419-27. doi: 10.1006/mcne.1999.0811. Mol Cell Neurosci. 1999. PMID: 10656250

9

Lipoprotein-associated PLA2 inhibition--a novel, non-lipid lowering strategy for atherosclerosis therapy.

Leach CA, Hickey DM, Ife RJ, Macphee CH, Smith SA, Tew DG. Leach CA, et al. Among authors: tew dg. Farmaco. 2001 Jan-Feb;56(1-2):45-50. doi: 10.1016/s0014-827x(01)01011-4. Farmaco. 2001. PMID: 11347966

10

Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase, is expressed by macrophages in human and rabbit atherosclerotic lesions.

Häkkinen T, Luoma JS, Hiltunen MO, Macphee CH, Milliner KJ, Patel L, Rice SQ, Tew DG, Karkola K, Ylä-Herttuala S. Häkkinen T, et al. Among authors: tew dg. Arterioscler Thromb Vasc Biol. 1999 Dec;19(12):2909-17. doi: 10.1161/01.atv.19.12.2909. Arterioscler Thromb Vasc Biol. 1999. PMID: 10591668

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