Clarke DM - Search Results

1

Cystic fibrosis: channel, catalytic, and folding properties of the CFTR protein.

Seibert FS, Loo TW, Clarke DM, Riordan JR. Seibert FS, et al. Among authors: clarke dm. J Bioenerg Biomembr. 1997 Oct;29(5):429-42. doi: 10.1023/a:1022478822214. J Bioenerg Biomembr. 1997. PMID: 9511928 Review.

2

Introduction of the most common cystic fibrosis mutation (Delta F508) into human P-glycoprotein disrupts packing of the transmembrane segments.

Loo TW, Bartlett MC, Clarke DM. Loo TW, et al. Among authors: clarke dm. J Biol Chem. 2002 Aug 2;277(31):27585-8. doi: 10.1074/jbc.C200330200. Epub 2002 Jun 17. J Biol Chem. 2002. PMID: 12070134 Free article.

3

The DeltaF508 mutation disrupts packing of the transmembrane segments of the cystic fibrosis transmembrane conductance regulator.

Chen EY, Bartlett MC, Loo TW, Clarke DM. Chen EY, et al. Among authors: clarke dm. J Biol Chem. 2004 Sep 17;279(38):39620-7. doi: 10.1074/jbc.M407887200. Epub 2004 Jul 21. J Biol Chem. 2004. PMID: 15272010 Free article.

4

Thapsigargin or curcumin does not promote maturation of processing mutants of the ABC transporters, CFTR, and P-glycoprotein.

Loo TW, Bartlett MC, Clarke DM. Loo TW, et al. Among authors: clarke dm. Biochem Biophys Res Commun. 2004 Dec 10;325(2):580-5. doi: 10.1016/j.bbrc.2004.10.070. Biochem Biophys Res Commun. 2004. PMID: 15530432

5

Rescue of DeltaF508 and other misprocessed CFTR mutants by a novel quinazoline compound.

Loo TW, Bartlett MC, Clarke DM. Loo TW, et al. Among authors: clarke dm. Mol Pharm. 2005 Sep-Oct;2(5):407-13. doi: 10.1021/mp0500521. Mol Pharm. 2005. PMID: 16196493

6

The chemical chaperone CFcor-325 repairs folding defects in the transmembrane domains of CFTR-processing mutants.

Loo TW, Bartlett MC, Wang Y, Clarke DM. Loo TW, et al. Among authors: clarke dm. Biochem J. 2006 May 1;395(3):537-42. doi: 10.1042/BJ20060013. Biochem J. 2006. PMID: 16417523 Free PMC article.

7

Using a cysteine-less mutant to provide insight into the structure and mechanism of CFTR.

Loo TW, Clarke DM. Loo TW, et al. Among authors: clarke dm. J Physiol. 2006 Apr 15;572(Pt 2):312. doi: 10.1113/jphysiol.2006.108159. Epub 2006 Feb 23. J Physiol. 2006. PMID: 16497707 Free PMC article. No abstract available.

8

Specific rescue of cystic fibrosis transmembrane conductance regulator processing mutants using pharmacological chaperones.

Wang Y, Bartlett MC, Loo TW, Clarke DM. Wang Y, et al. Among authors: clarke dm. Mol Pharmacol. 2006 Jul;70(1):297-302. doi: 10.1124/mol.106.023994. Epub 2006 Apr 19. Mol Pharmacol. 2006. PMID: 16624886

9

Rescue of folding defects in ABC transporters using pharmacological chaperones.

Loo TW, Bartlett MC, Clarke DM. Loo TW, et al. Among authors: clarke dm. J Bioenerg Biomembr. 2005 Dec;37(6):501-7. doi: 10.1007/s10863-005-9499-3. J Bioenerg Biomembr. 2005. PMID: 16691490 Review.

10

Modulating the folding of P-glycoprotein and cystic fibrosis transmembrane conductance regulator truncation mutants with pharmacological chaperones.

Wang Y, Loo TW, Bartlett MC, Clarke DM. Wang Y, et al. Among authors: clarke dm. Mol Pharmacol. 2007 Mar;71(3):751-8. doi: 10.1124/mol.106.029926. Epub 2006 Nov 28. Mol Pharmacol. 2007. PMID: 17132688

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