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A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.
Zhao ZS, Manser E, Chen XQ, Chong C, Leung T, Lim L. Zhao ZS, et al. Among authors: leung t. Mol Cell Biol. 1998 Apr;18(4):2153-63. doi: 10.1128/MCB.18.4.2153. Mol Cell Biol. 1998. PMID: 9528787 Free PMC article.
AlphaPAK in a constitutively active form can exert morphological effects (E. Manser, H.-Y. Huang, T.-H. Loo, X.-Q. Chen, J.-M. Dong, T. Leung, and L. Lim, Mol. Cell. Biol. 17:1129-1143, 1997) resembling those of Cdc42G12V. ...
AlphaPAK in a constitutively active form can exert morphological effects (E. Manser, H.-Y. Huang, T.-H. Loo, X.-Q. Chen, J.-M. Dong, …
A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes.
Leung T, Manser E, Tan L, Lim L. Leung T, et al. J Biol Chem. 1995 Dec 8;270(49):29051-4. doi: 10.1074/jbc.270.49.29051. J Biol Chem. 1995. PMID: 7493923 Free article.
We previously reported the cloning of a serine/threonine kinase, PAK (for p21 (Cdc42/Rac)-activated kinase), which binds to the Ras-related GTPases Cdc42Hs and Rac1 (Manser, E., Leung, T., Salihuddin, H., Zhao, Z-s., and Lim, L. (1994) Nature 367, 40-46). These p21 …
We previously reported the cloning of a serine/threonine kinase, PAK (for p21 (Cdc42/Rac)-activated kinase), which binds to the Ras-related …
Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family.
Manser E, Chong C, Zhao ZS, Leung T, Michael G, Hall C, Lim L. Manser E, et al. Among authors: leung t. J Biol Chem. 1995 Oct 20;270(42):25070-8. doi: 10.1074/jbc.270.42.25070. J Biol Chem. 1995. PMID: 7559638 Free article.
A number of "target" proteins for the Rho family of small GTP-binding proteins have now been identified, including the protein kinases ACK and p65PAK (Manser, E., Leung, T., Salihuddin, H., Zhao, Z.-S., and Lim, L. (1994) Nature 367, 40-46). The purified serine/thre …
A number of "target" proteins for the Rho family of small GTP-binding proteins have now been identified, including the protein kinases ACK a …
The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton.
Leung T, Chen XQ, Manser E, Lim L. Leung T, et al. Mol Cell Biol. 1996 Oct;16(10):5313-27. doi: 10.1128/MCB.16.10.5313. Mol Cell Biol. 1996. PMID: 8816443 Free PMC article.
We recently reported on a p150 serine/threonine kinase (termed ROK alpha) binding RhoA only in its active GTP-bound state and on its cDNA; introduction of RhoA into HeLa cells resulted in translocation of the cytoplasmic kinase to plasma membranes, consistent with ROK alpha being …
We recently reported on a p150 serine/threonine kinase (termed ROK alpha) binding RhoA only in its active GTP-bound state and on its cDNA; i …
2,337 results