García-Echeverría C - Search Results

1

Potent antagonists of the SH2 domain of Grb2: optimization of the X+1 position of 3-amino-Z-Tyr(PO3H2)-X+1-Asn-NH2.

García-Echeverría C, Furet P, Gay B, Fretz H, Rahuel J, Schoepfer J, Caravatti G. García-Echeverría C, et al. J Med Chem. 1998 May 21;41(11):1741-4. doi: 10.1021/jm970856n. J Med Chem. 1998. PMID: 9599224 No abstract available.

2

Discovery of 3-aminobenzyloxycarbonyl as an N-terminal group conferring high affinity to the minimal phosphopeptide sequence recognized by the Grb2-SH2 domain.

Furet P, Gay B, García-Echeverría C, Rahuel J, Fretz H, Schoepfer J, Caravatti G. Furet P, et al. J Med Chem. 1997 Oct 24;40(22):3551-6. doi: 10.1021/jm9702185. J Med Chem. 1997. PMID: 9357522

3

Structural basis for the high affinity of amino-aromatic SH2 phosphopeptide ligands.

Rahuel J, García-Echeverría C, Furet P, Strauss A, Caravatti G, Fretz H, Schoepfer J, Gay B. Rahuel J, et al. J Mol Biol. 1998 Jun 19;279(4):1013-22. doi: 10.1006/jmbi.1998.1790. J Mol Biol. 1998. PMID: 9642078

4

Structure-based design and synthesis of high affinity tripeptide ligands of the Grb2-SH2 domain.

Furet P, Gay B, Caravatti G, García-Echeverría C, Rahuel J, Schoepfer J, Fretz H. Furet P, et al. J Med Chem. 1998 Aug 27;41(18):3442-9. doi: 10.1021/jm980159a. J Med Chem. 1998. PMID: 9719597

5

Structure-based design of peptidomimetic ligands of the Grb2-SH2 domain.

Schoepfer J, Gay B, Caravatti G, Garcia-Echeverria C, Fretz H, Rahuel J, Furet P. Schoepfer J, et al. Bioorg Med Chem Lett. 1998 Oct 20;8(20):2865-70. doi: 10.1016/s0960-894x(98)00513-7. Bioorg Med Chem Lett. 1998. PMID: 9873638

6

Highly potent inhibitors of the Grb2-SH2 domain.

Schoepfer J, Fretz H, Gay B, Furet P, García-Echeverría C, End N, Caravatti G. Schoepfer J, et al. Bioorg Med Chem Lett. 1999 Jan 18;9(2):221-6. doi: 10.1016/s0960-894x(98)00701-x. Bioorg Med Chem Lett. 1999. PMID: 10021933

7

Structure-based design, synthesis, and X-ray crystallography of a high-affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic.

Furet P, García-Echeverría C, Gay B, Schoepfer J, Zeller M, Rahuel J. Furet P, et al. J Med Chem. 1999 Jul 1;42(13):2358-63. doi: 10.1021/jm991013u. J Med Chem. 1999. PMID: 10395476

8

Mapping the X(+1) binding site of the Grb2-SH2 domain with alpha,alpha-disubstituted cyclic alpha-amino acids.

García-Echeverría C, Gay B, Rahuel J, Furet P. García-Echeverría C, et al. Bioorg Med Chem Lett. 1999 Oct 18;9(20):2915-20. doi: 10.1016/s0960-894x(99)00501-6. Bioorg Med Chem Lett. 1999. PMID: 10571147

9

Discovery of potent antagonists of the interaction between human double minute 2 and tumor suppressor p53.

García-Echeverría C, Chène P, Blommers MJ, Furet P. García-Echeverría C, et al. J Med Chem. 2000 Aug 24;43(17):3205-8. doi: 10.1021/jm990966p. J Med Chem. 2000. PMID: 10966738 No abstract available.

10

Structure-based design and synthesis of phosphinate isosteres of phosphotyrosine for incorporation in Grb2-SH2 domain inhibitors. Part 1.

Furet P, Caravatti G, Denholm AA, Faessler A, Fretz H, García-Echeverría C, Gay B, Irving E, Press NJ, Rahuel J, Schoepfer J, Walker CV. Furet P, et al. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2337-41. doi: 10.1016/s0960-894x(00)00475-3. Bioorg Med Chem Lett. 2000. PMID: 11055351

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