Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival.
Olivera A, Kohama T, Edsall L, Nava V, Cuvillier O, Poulton S, Spiegel S.
Olivera A, et al.
J Cell Biol. 1999 Nov 1;147(3):545-58. doi: 10.1083/jcb.147.3.545.
J Cell Biol. 1999.
PMID: 10545499
Free PMC article.
However, the mitogenic and survival effects of exogenous SPP may not correlate with binding to cell-surface receptors (Van Brocklyn, J.R., M.J. Lee, R. Menzeleev, A. Olivera, L. Edsall, O. Cuvillier, D.M. Thomas, P.J.P. Coopman, S. Thangada, T. Hla, and S. ...The re …
However, the mitogenic and survival effects of exogenous SPP may not correlate with binding to cell-surface receptors (Van Brocklyn, J.R., M …