Velan B - Search Results

1

Functional characteristics of the oxyanion hole in human acetylcholinesterase.

Ordentlich A, Barak D, Kronman C, Ariel N, Segall Y, Velan B, Shafferman A. Ordentlich A, et al. Among authors: velan b. J Biol Chem. 1998 Jul 31;273(31):19509-17. doi: 10.1074/jbc.273.31.19509. J Biol Chem. 1998. PMID: 9677373 Free article.

2

The aromatic "trapping" of the catalytic histidine is essential for efficient catalysis in acetylcholinesterase.

Barak D, Kaplan D, Ordentlich A, Ariel N, Velan B, Shafferman A. Barak D, et al. Among authors: velan b. Biochemistry. 2002 Jul 2;41(26):8245-52. doi: 10.1021/bi020143t. Biochemistry. 2002. PMID: 12081473

3

Is aromaticity essential for trapping the catalytic histidine 447 in human acetylcholinesterase?

Kaplan D, Barak D, Ordentlich A, Kronman C, Velan B, Shafferman A. Kaplan D, et al. Among authors: velan b. Biochemistry. 2004 Mar 23;43(11):3129-36. doi: 10.1021/bi030206n. Biochemistry. 2004. PMID: 15023064

4

Stereoselectivity toward VX is determined by interactions with residues of the acyl pocket as well as of the peripheral anionic site of AChE.

Ordentlich A, Barak D, Sod-Moriah G, Kaplan D, Mizrahi D, Segall Y, Kronman C, Karton Y, Lazar A, Marcus D, Velan B, Shafferman A. Ordentlich A, et al. Among authors: velan b. Biochemistry. 2004 Sep 7;43(35):11255-65. doi: 10.1021/bi0490946. Biochemistry. 2004. PMID: 15366935

5

Functional requirements for the optimal catalytic configuration of the AChE active center.

Shafferman A, Barak D, Kaplan D, Ordentlich A, Kronman C, Velan B. Shafferman A, et al. Among authors: velan b. Chem Biol Interact. 2005 Dec 15;157-158:123-31. doi: 10.1016/j.cbi.2005.10.021. Epub 2005 Oct 27. Chem Biol Interact. 2005. PMID: 16256968

6

The role of AChE active site gorge in determining stereoselectivity of charged and noncharged VX enantiomers.

Ordentlich A, Barak D, Sod-Moriah G, Kaplan D, Mizrahi D, Segall Y, Kronman C, Karton Y, Lazar A, Marcus D, Velan B, Shafferman A. Ordentlich A, et al. Among authors: velan b. Chem Biol Interact. 2005 Dec 15;157-158:191-8. doi: 10.1016/j.cbi.2005.10.026. Epub 2005 Nov 10. Chem Biol Interact. 2005. PMID: 16289014

7

Host-regulated disposition of mammalian AChEs.

Kronman C, Cohen O, Velan B, Shafferman A. Kronman C, et al. Among authors: velan b. Chem Biol Interact. 2005 Dec 15;157-158:51-5. doi: 10.1016/j.cbi.2005.10.005. Epub 2005 Nov 9. Chem Biol Interact. 2005. PMID: 16289063

8

Lessons from functional analysis of AChE covalent and noncovalent inhibitors for design of AD therapeutic agents.

Barak D, Ordentlich A, Kaplan D, Kronman C, Velan B, Shafferman A. Barak D, et al. Among authors: velan b. Chem Biol Interact. 2005 Dec 15;157-158:219-26. doi: 10.1016/j.cbi.2005.10.030. Epub 2005 Nov 11. Chem Biol Interact. 2005. PMID: 16289124

9

Controlled concealment of exposed clearance and immunogenic domains by site-specific polyethylene glycol attachment to acetylcholinesterase hypolysine mutants.

Cohen O, Kronman C, Lazar A, Velan B, Shafferman A. Cohen O, et al. Among authors: velan b. J Biol Chem. 2007 Dec 7;282(49):35491-501. doi: 10.1074/jbc.M704785200. Epub 2007 Oct 11. J Biol Chem. 2007. PMID: 17932038 Free article.

10

Flexibility versus "rigidity" of the functional architecture of AChE active center.

Shafferman A, Barak D, Stein D, Kronman C, Velan B, Greig NH, Ordentlich A. Shafferman A, et al. Among authors: velan b. Chem Biol Interact. 2008 Sep 25;175(1-3):166-72. doi: 10.1016/j.cbi.2008.03.013. Epub 2008 Apr 8. Chem Biol Interact. 2008. PMID: 18471807 Free PMC article.

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