Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severity.
Van Acker GJ, Saluja AK, Bhagat L, Singh VP, Song AM, Steer ML.
Van Acker GJ, et al. Among authors: steer ml.
Am J Physiol Gastrointest Liver Physiol. 2002 Sep;283(3):G794-800. doi: 10.1152/ajpgi.00363.2001.
Am J Physiol Gastrointest Liver Physiol. 2002.
PMID: 12181196
Free article.
In previous in vitro studies, we have shown that intra-acinar cell activation of trypsinogen and acinar cell injury in response to supramaximal secretagogue stimulation could be prevented by the cell permeant cathepsin B inhibitor E64d (Saluja A, Donovan EA, Yamanaka K, Yamaguchi …
In previous in vitro studies, we have shown that intra-acinar cell activation of trypsinogen and acinar cell injury in response to supramaxi …