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Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects.
Masaki H, Kurihara T, Yamaki A, Inomata N, Nozawa Y, Mori Y, Murasawa S, Kizima K, Maruyama K, Horiuchi M, Dzau VJ, Takahashi H, Iwasaka T, Inada M, Matsubara H. Masaki H, et al. Among authors: murasawa s. J Clin Invest. 1998 Feb 1;101(3):527-35. doi: 10.1172/JCI1885. J Clin Invest. 1998. PMID: 9449684 Free PMC article.
Angiotensin II type 2 receptor is upregulated in human heart with interstitial fibrosis, and cardiac fibroblasts are the major cell type for its expression.
Tsutsumi Y, Matsubara H, Ohkubo N, Mori Y, Nozawa Y, Murasawa S, Kijima K, Maruyama K, Masaki H, Moriguchi Y, Shibasaki Y, Kamihata H, Inada M, Iwasaka T. Tsutsumi Y, et al. Among authors: murasawa s. Circ Res. 1998 Nov 16;83(10):1035-46. doi: 10.1161/01.res.83.10.1035. Circ Res. 1998. PMID: 9815151
Angiotensin II-induced transactivation of epidermal growth factor receptor regulates fibronectin and transforming growth factor-beta synthesis via transcriptional and posttranscriptional mechanisms.
Moriguchi Y, Matsubara H, Mori Y, Murasawa S, Masaki H, Maruyama K, Tsutsumi Y, Shibasaki Y, Tanaka Y, Nakajima T, Oda K, Iwasaka T. Moriguchi Y, et al. Among authors: murasawa s. Circ Res. 1999 May 14;84(9):1073-84. doi: 10.1161/01.res.84.9.1073. Circ Res. 1999. PMID: 10325245
70 results