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Reconstitution of insulin signaling pathways in rat 3Y1 cells lacking insulin receptor and insulin receptor substrate-1. Evidence that activation of Akt is insufficient for insulin-stimulated glycogen synthesis or glucose uptake in rat 3Y1 cells.
Imanaka T, Hayashi H, Kishi K, Wang L, Ishii K, Hazeki O, Katada T, Ebina Y. Imanaka T, et al. Among authors: ebina y. J Biol Chem. 1998 Sep 25;273(39):25347-55. doi: 10.1074/jbc.273.39.25347. J Biol Chem. 1998. PMID: 9738001 Free article.
Platelet-derived growth factor triggers translocation of the insulin-regulatable glucose transporter (type 4) predominantly through phosphatidylinositol 3-kinase binding sites on the receptor.
Kamohara S, Hayashi H, Todaka M, Kanai F, Ishii K, Imanaka T, Escobedo JA, Williams LT, Ebina Y. Kamohara S, et al. Among authors: ebina y. Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):1077-81. doi: 10.1073/pnas.92.4.1077. Proc Natl Acad Sci U S A. 1995. PMID: 7862637 Free PMC article.
Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase.
Kanai F, Ito K, Todaka M, Hayashi H, Kamohara S, Ishii K, Okada T, Hazeki O, Ui M, Ebina Y. Kanai F, et al. Among authors: ebina y. Biochem Biophys Res Commun. 1993 Sep 15;195(2):762-8. doi: 10.1006/bbrc.1993.2111. Biochem Biophys Res Commun. 1993. PMID: 8396927
We had already developed a novel cell line to detect GLUT4 on the cell surface, directly and sensitively (Kanai, F., Nishioka, Y., Hayashi, H., Kamohara, S., Todaka, M., and Ebina, Y. (1993) J. Biol. Chem. 268, 14523-14526). ...
We had already developed a novel cell line to detect GLUT4 on the cell surface, directly and sensitively (Kanai, F., Nishioka, Y., Ha …
344 results