Dale IL - Search Results

1

Reversal of P-glycoprotein-mediated multidrug resistance by XR9051, a novel diketopiperazine derivative.

Dale IL, Tuffley W, Callaghan R, Holmes JA, Martin K, Luscombe M, Mistry P, Ryder H, Stewart AJ, Charlton P, Twentyman PR, Bevan P. Dale IL, et al. Br J Cancer. 1998 Oct;78(7):885-92. doi: 10.1038/bjc.1998.597. Br J Cancer. 1998. PMID: 9764579 Free PMC article.

2

In vivo efficacy of XR9051, a potent modulator of P-glycoprotein mediated multidrug resistance.

Mistry P, Plumb J, Eccles S, Watson S, Dale I, Ryder H, Box G, Charlton P, Templeton D, Bevan PB. Mistry P, et al. Br J Cancer. 1999 Apr;79(11-12):1672-8. doi: 10.1038/sj.bjc.6690267. Br J Cancer. 1999. PMID: 10206276 Free PMC article.

3

Studies on quinazolinones as dual inhibitors of Pgp and MRP1 in multidrug resistance.

Wang S, Ryder H, Pretswell I, Depledge P, Milton J, Hancox TC, Dale I, Dangerfield W, Charlton P, Faint R, Dodd R, Hassan S. Wang S, et al. Bioorg Med Chem Lett. 2002 Feb 25;12(4):571-4. doi: 10.1016/s0960-894x(01)00804-6. Bioorg Med Chem Lett. 2002. PMID: 11844674

4

Effects of activators of protein kinase C, including bryostatins 1 and 2, on the growth of A549 human lung carcinoma cells.

Dale IL, Gescher A. Dale IL, et al. Int J Cancer. 1989 Jan 15;43(1):158-63. doi: 10.1002/ijc.2910430129. Int J Cancer. 1989. PMID: 2910827

5

Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models.

Winter-Holt JJ, Bardelle C, Chiarparin E, Dale IL, Davey PRJ, Davies NL, Denz C, Fillery SM, Guérot CM, Han F, Hughes SJ, Kulkarni M, Liu Z, Milbradt A, Moss TA, Niu H, Patel J, Rabow AA, Schimpl M, Shi J, Sun D, Yang D, Guichard S. Winter-Holt JJ, et al. Among authors: dale il. J Med Chem. 2022 Feb 24;65(4):3306-3331. doi: 10.1021/acs.jmedchem.1c01871. Epub 2022 Feb 8. J Med Chem. 2022. PMID: 35133824

6

Discovery of a selective c-MET inhibitor with a novel binding mode.

Collie GW, Barlind L, Bazzaz S, Börjesson U, Dale IL, Disch JS, Habeshian S, Jetson R, Khurana P, Madin A, Michaelides IN, Peng L, Snijder A, Stubbs CJ. Collie GW, et al. Among authors: dale il. Bioorg Med Chem Lett. 2022 Nov 1;75:128948. doi: 10.1016/j.bmcl.2022.128948. Epub 2022 Aug 17. Bioorg Med Chem Lett. 2022. PMID: 35987508 Free article.

7

Protein kinase C--a novel target for rational anti-cancer drug design?

Gescher A, Dale IL. Gescher A, et al. Among authors: dale il. Anticancer Drug Des. 1989 Aug;4(2):93-105. Anticancer Drug Des. 1989. PMID: 2679620 Review. No abstract available.

8

Comparison of effects of bryostatins 1 and 2 and 12-O-tetradecanoylphorbol-13-acetate on protein kinase C activity in A549 human lung carcinoma cells.

Dale IL, Bradshaw TD, Gescher A, Pettit GR. Dale IL, et al. Cancer Res. 1989 Jun 15;49(12):3242-5. Cancer Res. 1989. PMID: 2720677

9

Studies on bioactive compounds. 13. Synthesis and lack of growth-inhibitory properties of cyclohexane-1,2,4-triol 1,2-diesters, which resemble ring C of the phorbol ester molecule.

Laughton CA, Dale IL, Gescher A. Laughton CA, et al. Among authors: dale il. J Med Chem. 1989 Feb;32(2):428-33. doi: 10.1021/jm00122a023. J Med Chem. 1989. PMID: 2913303

10

Effect of two inducers of cellular differentiation on the glutathione status of human HL-60 promyelocytic leukaemia and A549 lung carcinoma cells.

Lazenby CM, Gescher A, Dale IL. Lazenby CM, et al. Among authors: dale il. Biochem Pharmacol. 1987 Sep 1;36(17):2869-71. doi: 10.1016/0006-2952(87)90280-2. Biochem Pharmacol. 1987. PMID: 3477230 No abstract available.

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