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The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo.
Gaster LM, Blaney FE, Davies S, Duckworth DM, Ham P, Jenkins S, Jennings AJ, Joiner GF, King FD, Mulholland KR, Wyman PA, Hagan JJ, Hatcher J, Jones BJ, Middlemiss DN, Price GW, Riley G, Roberts C, Routledge C, Selkirk J, Slade PD. Gaster LM, et al. Among authors: jones bj. J Med Chem. 1998 Apr 9;41(8):1218-35. doi: 10.1021/jm970457s. J Med Chem. 1998. PMID: 9548813
Species differences in 5-HT autoreceptors.
Price GW, Roberts C, Watson J, Burton M, Mulholland K, Middlemiss DN, Jones BJ. Price GW, et al. Among authors: jones bj. Behav Brain Res. 1996;73(1-2):79-82. doi: 10.1016/0166-4328(96)00074-5. Behav Brain Res. 1996. PMID: 8788481
The medical benefit of 5-HT research.
Jones BJ, Blackburn TP. Jones BJ, et al. Pharmacol Biochem Behav. 2002 Apr;71(4):555-68. doi: 10.1016/s0091-3057(01)00745-6. Pharmacol Biochem Behav. 2002. PMID: 11888547 Review.
252 results