Maley F - Search Results

1

Probing the folate-binding site of human thymidylate synthase by site-directed mutagenesis. Generation of mutants that confer resistance to raltitrexed, Thymitaq, and BW1843U89.

Tong Y, Liu-Chen X, Ercikan-Abali EA, Zhao SC, Banerjee D, Maley F, Bertino JR. Tong Y, et al. Among authors: maley f. J Biol Chem. 1998 Nov 20;273(47):31209-14. doi: 10.1074/jbc.273.47.31209. J Biol Chem. 1998. PMID: 9813027 Free article.

2

Retroviral transduction of a mutant dihydrofolate reductase-thymidylate synthase fusion gene into murine marrow cells confers resistance to both methotrexate and 5-fluorouracil.

Capiaux GM, Budak-Alpdogan T, Takebe N, Mayer-Kuckuk P, Banerjee D, Maley F, Bertino JR. Capiaux GM, et al. Among authors: maley f. Hum Gene Ther. 2003 Mar 20;14(5):435-46. doi: 10.1089/104303403321467207. Hum Gene Ther. 2003. PMID: 12691609

3

Protection of hematopoietic stem cells from pemetrexed toxicity by retroviral gene transfer with a mutant dihydrofolate reductase-mutant thymidylate synthase fusion gene.

Capiaux GM, Budak-Alpdogan T, Alpdogan O, Bornmann W, Takebe N, Banerjee D, Maley F, Bertino JR. Capiaux GM, et al. Among authors: maley f. Cancer Gene Ther. 2004 Dec;11(12):767-73. doi: 10.1038/sj.cgt.7700683. Cancer Gene Ther. 2004. PMID: 15359285

4

Properties of a defined mutant of Escherichia coli thymidylate synthase.

Maley GF, Maley F. Maley GF, et al. Among authors: maley f. J Biol Chem. 1988 Jun 5;263(16):7620-7. J Biol Chem. 1988. PMID: 3286637 Free article.

5

Intracellular location of thymidylate synthase and its state of phosphorylation.

Samsonoff WA, Reston J, McKee M, O'Connor B, Galivan J, Maley G, Maley F. Samsonoff WA, et al. Among authors: maley f, maley g. J Biol Chem. 1997 May 16;272(20):13281-5. doi: 10.1074/jbc.272.20.13281. J Biol Chem. 1997. PMID: 9148948 Free article.

6

Identification of an active-site residue in yeast invertase by affinity labeling and site-directed mutagenesis.

Reddy VA, Maley F. Reddy VA, et al. Among authors: maley f. J Biol Chem. 1990 Jul 5;265(19):10817-20. J Biol Chem. 1990. PMID: 2113524 Free article.

7

The effect of reducing reagents on binding of thymidylate synthase protein to thymidylate synthase messenger RNA.

Chu E, Voeller DM, Morrison PF, Jones KL, Takechi T, Maley GF, Maley F, Allegra CJ. Chu E, et al. Among authors: maley f, maley gf. J Biol Chem. 1994 Aug 12;269(32):20289-93. J Biol Chem. 1994. PMID: 8051122 Free article.

8

Studies on identifying the catalytic role of Glu-204 in the active site of yeast invertase.

Reddy A, Maley F. Reddy A, et al. Among authors: maley f. J Biol Chem. 1996 Jun 14;271(24):13953-7. doi: 10.1074/jbc.271.24.13953. J Biol Chem. 1996. PMID: 8662946 Free article.

In a previous study on yeast invertase (Reddy, A., and Maley, F. (1990) J. Biol. Chem. 265, 10817-10820), we identified Asp-23 through the procedures of affinity labeling and site-directed mutagenesis as a catalytic nucleophile. ...

In a previous study on yeast invertase (Reddy, A., and Maley, F. (1990) J. Biol. Chem. 265, 10817-10820), we identified Asp-23 …

9

Mode of action of site-directed irreversible folate analogue inhibitors of thymidylate synthase.

Lobo AP, Nair MG, Changchien L, Weichsel A, Montfort WR, Maley F. Lobo AP, et al. Among authors: maley f. Biochemistry. 1998 Mar 31;37(13):4535-42. doi: 10.1021/bi9717284. Biochemistry. 1998. PMID: 9521774

Similar to previously described Lactobacillus casei TS inhibition studies with sulfhydryl reagents [Galivan, J., Noonan, J., and Maley, F. (1977) Arch. Biochem. Biophys. 184, 336-345], the kinetics of inhibition suggested that complete inhibition occurs on reaction …

Similar to previously described Lactobacillus casei TS inhibition studies with sulfhydryl reagents [Galivan, J., Noonan, J., and Maley …

10

Properties of bacteriophage T4 thymidylate synthase following mutagenic changes in the active site and folate binding region.

LaPat-Polasko L, Maley GF, Maley F. LaPat-Polasko L, et al. Among authors: maley f, maley gf. Biochemistry. 1990 Oct 16;29(41):9561-72. doi: 10.1021/bi00493a010. Biochemistry. 1990. PMID: 2271601

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