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Characterization of isoleucyl-tRNA synthetase from Staphylococcus aureus. II. Mechanism of inhibition by reaction intermediate and pseudomonic acid analogues studied using transient and steady-state kinetics.
Pope AJ, Moore KJ, McVey M, Mensah L, Benson N, Osbourne N, Broom N, Brown MJ, O'Hanlon P. Pope AJ, et al. Among authors: mensah l. J Biol Chem. 1998 Nov 27;273(48):31691-701. doi: 10.1074/jbc.273.48.31691. J Biol Chem. 1998. PMID: 9822630 Free article.
The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase.
Brown MJ, Carter PS, Fenwick AS, Fosberry AP, Hamprecht DW, Hibbs MJ, Jarvest RL, Mensah L, Milner PH, O'Hanlon PJ, Pope AJ, Richardson CM, West A, Witty DR. Brown MJ, et al. Among authors: mensah l. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3171-4. doi: 10.1016/s0960-894x(02)00604-2. Bioorg Med Chem Lett. 2002. PMID: 12372526
59 results