Groot PH - Search Results

1

Identification of a truncated form of the CC chemokine CK beta-8 demonstrating greatly enhanced biological activity.

Macphee CH, Appelbaum ER, Johanson K, Moores KE, Imburgia CS, Fornwald J, Berkhout T, Brawner M, Groot PH, O'Donnell K, O'Shannessy D, Scott G, White JR. Macphee CH, et al. Among authors: groot ph. J Immunol. 1998 Dec 1;161(11):6273-9. J Immunol. 1998. PMID: 9834116

2

Fractalkine is expressed by smooth muscle cells in response to IFN-gamma and TNF-alpha and is modulated by metalloproteinase activity.

Ludwig A, Berkhout T, Moores K, Groot P, Chapman G. Ludwig A, et al. J Immunol. 2002 Jan 15;168(2):604-12. doi: 10.4049/jimmunol.168.2.604. J Immunol. 2002. PMID: 11777952

3

Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B.

Berkhout TA, Sarau HM, Moores K, White JR, Elshourbagy N, Appelbaum E, Reape RJ, Brawner M, Makwana J, Foley JJ, Schmidt DB, Imburgia C, McNulty D, Matthews J, O'Donnell K, O'Shannessy D, Scott M, Groot PH, Macphee C. Berkhout TA, et al. Among authors: groot ph. J Biol Chem. 1997 Jun 27;272(26):16404-13. doi: 10.1074/jbc.272.26.16404. J Biol Chem. 1997. PMID: 9195948 Free article.

4

Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1).

Berkhout TA, Gohil J, Gonzalez P, Nicols CL, Moores KE, Macphee CH, White JR, Groot PH. Berkhout TA, et al. Among authors: groot ph. Biochem Pharmacol. 2000 Mar 1;59(5):591-6. doi: 10.1016/s0006-2952(99)00354-8. Biochem Pharmacol. 2000. PMID: 10660125

5

CCR2B receptor antagonists: conversion of a weak HTS hit to a potent lead compound.

Forbes IT, Cooper DG, Dodds EK, Hickey DM, Ife RJ, Meeson M, Stockley M, Berkhout TA, Gohil J, Groot PH, Moores K. Forbes IT, et al. Among authors: groot ph. Bioorg Med Chem Lett. 2000 Aug 21;10(16):1803-6. doi: 10.1016/s0960-894x(00)00347-4. Bioorg Med Chem Lett. 2000. PMID: 10969972

6

CCR2: characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach.

Berkhout TA, Blaney FE, Bridges AM, Cooper DG, Forbes IT, Gribble AD, Groot PH, Hardy A, Ife RJ, Kaur R, Moores KE, Shillito H, Willetts J, Witherington J. Berkhout TA, et al. Among authors: groot ph. J Med Chem. 2003 Sep 11;46(19):4070-86. doi: 10.1021/jm030862l. J Med Chem. 2003. PMID: 12954060

7

SR-12813 lowers plasma cholesterol in beagle dogs by decreasing cholesterol biosynthesis.

Berkhout TA, Simon HM, Jackson B, Yates J, Pearce N, Groot PH, Bentzen C, Niesor E, Kerns WD, Suckling KE. Berkhout TA, et al. Among authors: groot ph. Atherosclerosis. 1997 Sep;133(2):203-12. doi: 10.1016/s0021-9150(97)00131-7. Atherosclerosis. 1997. PMID: 9298680

8

The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076.

Pearce NJ, Yates JW, Berkhout TA, Jackson B, Tew D, Boyd H, Camilleri P, Sweeney P, Gribble AD, Shaw A, Groot PH. Pearce NJ, et al. Among authors: groot ph. Biochem J. 1998 Aug 15;334 ( Pt 1)(Pt 1):113-9. doi: 10.1042/bj3340113. Biochem J. 1998. PMID: 9693110 Free PMC article.

9

Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists.

Witherington J, Bordas V, Cooper DG, Forbes IT, Gribble AD, Ife RJ, Berkhout T, Gohil J, Groot PH. Witherington J, et al. Among authors: groot ph. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2177-80. doi: 10.1016/s0960-894x(01)00397-3. Bioorg Med Chem Lett. 2001. PMID: 11514164

10

Time-course studies by synchrotron X-ray solution scattering of the structure of human low-density lipoprotein during Cu(2+)-induced oxidation in relation to changes in lipid composition.

Meyer DF, Nealis AS, Macphee CH, Groot PH, Suckling KE, Bruckdorfer KR, Perkins SJ. Meyer DF, et al. Among authors: groot ph. Biochem J. 1996 Oct 1;319 ( Pt 1)(Pt 1):217-27. doi: 10.1042/bj3190217. Biochem J. 1996. PMID: 8870672 Free PMC article.

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