Meng YG - Search Results

1

Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of a humanized monoclonal antibody against vascular endothelial growth factor.

Lin YS, Nguyen C, Mendoza JL, Escandon E, Fei D, Meng YG, Modi NB. Lin YS, et al. Among authors: meng yg. J Pharmacol Exp Ther. 1999 Jan;288(1):371-8. J Pharmacol Exp Ther. 1999. PMID: 9862791

2

Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125I-labeled full-length and Fab antibodies in rhesus monkeys following intravitreal administration.

Mordenti J, Cuthbertson RA, Ferrara N, Thomsen K, Berleau L, Licko V, Allen PC, Valverde CR, Meng YG, Fei DT, Fourre KM, Ryan AM. Mordenti J, et al. Among authors: meng yg. Toxicol Pathol. 1999 Sep-Oct;27(5):536-44. doi: 10.1177/019262339902700507. Toxicol Pathol. 1999. PMID: 10528633

3

Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders.

Presta LG, Chen H, O'Connor SJ, Chisholm V, Meng YG, Krummen L, Winkler M, Ferrara N. Presta LG, et al. Among authors: meng yg. Cancer Res. 1997 Oct 15;57(20):4593-9. Cancer Res. 1997. PMID: 9377574

4

Efficacy and concentration-response of murine anti-VEGF monoclonal antibody in tumor-bearing mice and extrapolation to humans.

Mordenti J, Thomsen K, Licko V, Chen H, Meng YG, Ferrara N. Mordenti J, et al. Among authors: meng yg. Toxicol Pathol. 1999 Jan-Feb;27(1):14-21. doi: 10.1177/019262339902700104. Toxicol Pathol. 1999. PMID: 10367667

5

Complex formation of anti-VEGF-C with VEGF-C released during blood coagulation resulted in an artifact in its serum pharmacokinetics.

Bumbaca Yadav D, Reyes AE 2nd, Gupta P, Vernes JM, Meng YG, Schweiger MG, Stainton SL, Fuh G, Fielder PJ, Kamath AV, Shen BQ. Bumbaca Yadav D, et al. Among authors: meng yg. Pharmacol Res Perspect. 2020 Apr;8(2):e00573. doi: 10.1002/prp2.573. Pharmacol Res Perspect. 2020. PMID: 32125783 Free PMC article.

6

Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF.

Liang WC, Wu X, Peale FV, Lee CV, Meng YG, Gutierrez J, Fu L, Malik AK, Gerber HP, Ferrara N, Fuh G. Liang WC, et al. Among authors: meng yg. J Biol Chem. 2006 Jan 13;281(2):951-61. doi: 10.1074/jbc.M508199200. Epub 2005 Nov 7. J Biol Chem. 2006. PMID: 16278208 Free article.

7

Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis.

Shifren JL, Tseng JF, Zaloudek CJ, Ryan IP, Meng YG, Ferrara N, Jaffe RB, Taylor RN. Shifren JL, et al. Among authors: meng yg. J Clin Endocrinol Metab. 1996 Aug;81(8):3112-8. doi: 10.1210/jcem.81.8.8768883. J Clin Endocrinol Metab. 1996. PMID: 8768883

8

Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodies.

Gerber HP, Wu X, Yu L, Wiesmann C, Liang XH, Lee CV, Fuh G, Olsson C, Damico L, Xie D, Meng YG, Gutierrez J, Corpuz R, Li B, Hall L, Rangell L, Ferrando R, Lowman H, Peale F, Ferrara N. Gerber HP, et al. Among authors: meng yg. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3478-83. doi: 10.1073/pnas.0611492104. Epub 2007 Feb 20. Proc Natl Acad Sci U S A. 2007. PMID: 17360669 Free PMC article.

9

Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge.

Li B, Tesar D, Boswell CA, Cahaya HS, Wong A, Zhang J, Meng YG, Eigenbrot C, Pantua H, Diao J, Kapadia SB, Deng R, Kelley RF. Li B, et al. Among authors: meng yg. MAbs. 2014;6(5):1255-64. doi: 10.4161/mabs.29809. Epub 2014 Oct 30. MAbs. 2014. PMID: 25517310 Free PMC article.

10

Intraocular pharmacokinetics and safety of a humanized monoclonal antibody in rabbits after intravitreal administration of a solution or a PLGA microsphere formulation.

Mordenti J, Thomsen K, Licko V, Berleau L, Kahn JW, Cuthbertson RA, Duenas ET, Ryan AM, Schofield C, Berger TW, Meng YG, Cleland J. Mordenti J, et al. Among authors: meng yg. Toxicol Sci. 1999 Nov;52(1):101-6. doi: 10.1093/toxsci/52.1.101. Toxicol Sci. 1999. PMID: 10568703

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