Ngu K - Search Results

1

Malonyl alpha-mercaptoketones and alpha-mercaptoalcohols, a new class of matrix metalloproteinase inhibitors.

Campbell DA, Xiao XY, Harris D, Ida S, Mortezaei R, Ngu K, Shi L, Tien D, Wang Y, Navre M, Patel DV, Sharr MA, DiJoseph JF, Killar LM, Leone CL, Levin JI, Skotnicki JS. Campbell DA, et al. Among authors: ngu k. Bioorg Med Chem Lett. 1998 May 19;8(10):1157-62. doi: 10.1016/s0960-894x(98)00185-1. Bioorg Med Chem Lett. 1998. PMID: 9871727

2

A New and Efficient Solid Phase Synthesis of Hydroxamic Acids.

Ngu K, Patel DV. Ngu K, et al. J Org Chem. 1997 Oct 17;62(21):7088-7089. doi: 10.1021/jo971274g. J Org Chem. 1997. PMID: 11671806 No abstract available.

3

Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase.

Weinstein DS, Liu W, Gu Z, Langevine C, Ngu K, Fadnis L, Combs DW, Sitkoff D, Ahmad S, Zhuang S, Chen X, Wang FL, Loughney DA, Atwal KS, Zahler R, Macor JE, Madsen CS, Murugesan N. Weinstein DS, et al. Among authors: ngu k. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1435-40. doi: 10.1016/j.bmcl.2004.12.081. Bioorg Med Chem Lett. 2005. PMID: 15713402

4

Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase.

Ngu K, Weinstein DS, Liu W, Langevine C, Combs DW, Zhuang S, Chen X, Madsen CS, Harper TW, Ahmad S, Robl JA. Ngu K, et al. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4141-5. doi: 10.1016/j.bmcl.2011.05.107. Epub 2011 Jun 6. Bioorg Med Chem Lett. 2011. PMID: 21696952

5

Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches.

Xiao HY, Li N, Duan JJ, Jiang B, Lu Z, Ngu K, Tino J, Kopcho LM, Lu H, Chen J, Tebben AJ, Sheriff S, Chang CY, Yanchunas J Jr, Calambur D, Gao M, Shuster DJ, Susulic V, Xie JH, Guarino VR, Wu DR, Gregor KR, Goldstine CB, Hynes J Jr, Macor JE, Salter-Cid L, Burke JR, Shaw PJ, Dhar TGM. Xiao HY, et al. Among authors: ngu k. J Med Chem. 2020 Dec 10;63(23):15050-15071. doi: 10.1021/acs.jmedchem.0c01732. Epub 2020 Dec 1. J Med Chem. 2020. PMID: 33261314

6

Arylcyclopropanecarboxyl guanidines as novel, potent, and selective inhibitors of the sodium hydrogen exchanger isoform-1.

Ahmad S, Doweyko LM, Dugar S, Grazier N, Ngu K, Wu SC, Yost KJ, Chen BC, Gougoutas JZ, DiMarco JD, Lan SJ, Gavin BJ, Chen AY, Dorso CR, Serafino R, Kirby M, Atwal KS. Ahmad S, et al. Among authors: ngu k. J Med Chem. 2001 Sep 27;44(20):3302-10. doi: 10.1021/jm010100v. J Med Chem. 2001. PMID: 11563929

7

Aminoimidazoles as bioisosteres of acylguanidines: novel, potent, selective and orally bioavailable inhibitors of the sodium hydrogen exchanger isoform-1.

Ahmad S, Ngu K, Combs DW, Wu SC, Weinstein DS, Liu W, Chen BC, Chandrasena G, Dorso CR, Kirby M, Atwal KS. Ahmad S, et al. Among authors: ngu k. Bioorg Med Chem Lett. 2004 Jan 5;14(1):177-80. doi: 10.1016/j.bmcl.2003.09.066. Bioorg Med Chem Lett. 2004. PMID: 14684323

8

Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agents.

Ahmad S, Ngu K, Miller KJ, Wu G, Hung CP, Malmstrom S, Zhang G, O'Tanyi E, Keim WJ, Cullen MJ, Rohrbach KW, Thomas M, Ung T, Qu Q, Gan J, Narayanan R, Pelleymounter MA, Robl JA. Ahmad S, et al. Among authors: ngu k. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1128-33. doi: 10.1016/j.bmcl.2009.12.014. Epub 2009 Dec 6. Bioorg Med Chem Lett. 2010. PMID: 20022752

9

Synthesis and Antiobesity Properties of 6-(4-Chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one (BMS-814580): A Highly Efficacious Melanin Concentrating Hormone Receptor 1 (MCHR1) Inhibitor.

Ahmad S, Washburn WN, Hernandez AS, Bisaha S, Ngu K, Wang W, Pelleymounter MA, Longhi D, Flynn N, Azzara AV, Rohrbach K, Devenny J, Rooney S, Thomas M, Glick S, Godonis H, Harvey S, Zhang H, Gemzik B, Janovitz EB, Huang C, Zhang L, Robl JA, Murphy BJ. Ahmad S, et al. Among authors: ngu k. J Med Chem. 2016 Oct 13;59(19):8848-8858. doi: 10.1021/acs.jmedchem.6b00676. Epub 2016 Sep 15. J Med Chem. 2016. PMID: 27564419

10

Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: highly potent against human enzyme within a cellular environment.

Weinstein DS, Liu W, Ngu K, Langevine C, Combs DW, Zhuang S, Chen C, Madsen CS, Harper TW, Robl JA. Weinstein DS, et al. Among authors: ngu k. Bioorg Med Chem Lett. 2007 Sep 15;17(18):5115-20. doi: 10.1016/j.bmcl.2007.07.011. Epub 2007 Jul 13. Bioorg Med Chem Lett. 2007. PMID: 17656086

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