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trans-3-Benzyl-4-hydroxy-7-chromanylbenzoic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor.
Reiter LA, Koch K, Piscopio AD, Showell HJ, Alpert R, Biggers MS, Chambers RJ, Conklyn MJ, Cooper K, Cortina SR, Dibrino JN, Dominy BW, Farrell CA, Hingorani GP, Martinelli GJ, Ramchandani M, Wright KF. Reiter LA, et al. Among authors: showell hj. Bioorg Med Chem Lett. 1998 Jul 21;8(14):1781-6. doi: 10.1016/s0960-894x(98)00275-3. Bioorg Med Chem Lett. 1998. PMID: 9873433
(+)-1-(3S,4R)-[3-(4-phenylbenzyl)-4-hydroxychroman-7-yl]cyclopentane carboxylic acid, a highly potent, selective leukotriene B4 antagonist with oral activity in the murine collagen-induced arthritis model.
Koch K, Melvin LS Jr, Reiter LA, Biggers MS, Showell HJ, Griffiths RJ, Pettipher ER, Cheng JB, Milici AJ, Breslow R, et al. Koch K, et al. Among authors: showell hj. J Med Chem. 1994 Sep 30;37(20):3197-9. doi: 10.1021/jm00046a001. J Med Chem. 1994. PMID: 7932545 No abstract available.
100 results