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Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 3. Synthesis and biological activities of oxazolecarboxamide-substituted omega-phenyl-omega-(3-pyridyl)alkenoic acid derivatives and related compounds.
Takeuchi K, Kohn TJ, True TA, Mais DE, Wikel JH, Utterback BG, Wyss VL, Jakubowski JA. Takeuchi K, et al. Among authors: wyss vl. J Med Chem. 1998 Dec 31;41(27):5362-74. doi: 10.1021/jm980173n. J Med Chem. 1998. PMID: 9876106
Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition--I. Synthesis, structure-activity relationship, and evaluation of substituted omega-phenyl-omega-(3-pyridyl)alkenoic acids.
Takeuchi K, Happ AM, Mais DE, Layman N, Utterback BG, Wyss VL, Jakubowski JA. Takeuchi K, et al. Among authors: wyss vl. Bioorg Med Chem. 1994 Aug;2(8):743-55. doi: 10.1016/s0968-0896(00)82174-4. Bioorg Med Chem. 1994. PMID: 7894968
Fused bicyclic Gly-Asp beta-turn mimics with potent affinity for GPIIb-IIIa. Exploration of the arginine isostere.
Fisher MJ, Giese U, Harms CS, Kinnick MD, Lindstrom TD, McCowan JR, Mest HJ, Morin JM Jr, Mullaney JT, Paal M, Rapp A, Rühter G, Ruterbories KJ, Sall DJ, Scarborough RM, Schotten T, Stenzel W, Towner RD, Um SL, Utterback BG, Wyss VL, Jakubowski JA. Fisher MJ, et al. Among authors: wyss vl. Bioorg Med Chem Lett. 2000 Feb 21;10(4):385-9. doi: 10.1016/s0960-894x(00)00008-1. Bioorg Med Chem Lett. 2000. PMID: 10714506
Fibrinogen receptor (GPIIb-IIIa) antagonists derived from 5,6-bicyclic templates. Amidinoindoles, amidinoindazoles, and amidinobenzofurans containing the N-alpha-sulfonamide carboxylic acid function as potent platelet aggregation inhibitors.
Su T, Naughton MA, Smyth MS, Rose JW, Arfsten AE, McCowan JR, Jakubowski JA, Wyss VL, Ruterbories KJ, Sall DJ, Scarborough RM. Su T, et al. Among authors: wyss vl. J Med Chem. 1997 Dec 19;40(26):4308-18. doi: 10.1021/jm9704863. J Med Chem. 1997. PMID: 9435900
19 results