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The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues.
Girbal-Neuhauser E, Durieux JJ, Arnaud M, Dalbon P, Sebbag M, Vincent C, Simon M, Senshu T, Masson-Bessière C, Jolivet-Reynaud C, Jolivet M, Serre G. Girbal-Neuhauser E, et al. Among authors: durieux jj. J Immunol. 1999 Jan 1;162(1):585-94. J Immunol. 1999. PMID: 9886436
In the rheumatoid pannus, anti-filaggrin autoantibodies are produced by local plasma cells and constitute a higher proportion of IgG than in synovial fluid and serum.
Masson-Bessière C, Sebbag M, Durieux JJ, Nogueira L, Vincent C, Girbal-Neuhauser E, Durroux R, Cantagrel A, Serre G. Masson-Bessière C, et al. Among authors: durieux jj. Clin Exp Immunol. 2000 Mar;119(3):544-52. doi: 10.1046/j.1365-2249.2000.01171.x. Clin Exp Immunol. 2000. PMID: 10691929 Free PMC article.
CD14 is expressed and functional in human B cells.
Ziegler-Heitbrock HW, Pechumer H, Petersmann I, Durieux JJ, Vita N, Labeta MO, Ströbel M. Ziegler-Heitbrock HW, et al. Among authors: durieux jj. Eur J Immunol. 1994 Aug;24(8):1937-40. doi: 10.1002/eji.1830240835. Eur J Immunol. 1994. PMID: 7520002