Kelly JW - Search Results

1

Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation.

Lashuel HA, Lai Z, Kelly JW. Lashuel HA, et al. Among authors: kelly jw. Biochemistry. 1998 Dec 22;37(51):17851-64. doi: 10.1021/bi981876+. Biochemistry. 1998. PMID: 9922152

2

Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro.

Colon W, Kelly JW. Colon W, et al. Among authors: kelly jw. Biochemistry. 1992 Sep 15;31(36):8654-60. doi: 10.1021/bi00151a036. Biochemistry. 1992. PMID: 1390650

3

Comparison of lethal and nonlethal transthyretin variants and their relationship to amyloid disease.

McCutchen SL, Lai Z, Miroy GJ, Kelly JW, Colón W. McCutchen SL, et al. Among authors: kelly jw. Biochemistry. 1995 Oct 17;34(41):13527-36. doi: 10.1021/bi00041a032. Biochemistry. 1995. PMID: 7577941

4

Transthyretin mutation Leu-55-Pro significantly alters tetramer stability and increases amyloidogenicity.

McCutchen SL, Colon W, Kelly JW. McCutchen SL, et al. Among authors: kelly jw. Biochemistry. 1993 Nov 16;32(45):12119-27. doi: 10.1021/bi00096a024. Biochemistry. 1993. PMID: 8218290

5

Intermolecular disulfide linkages are not required for transthyretin amyloid fibril formation in vitro.

McCutchen SL, Kelly JW. McCutchen SL, et al. Among authors: kelly jw. Biochem Biophys Res Commun. 1993 Dec 15;197(2):415-21. doi: 10.1006/bbrc.1993.2495. Biochem Biophys Res Commun. 1993. PMID: 8267575

6

The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid.

Lai Z, Colón W, Kelly JW. Lai Z, et al. Among authors: kelly jw. Biochemistry. 1996 May 21;35(20):6470-82. doi: 10.1021/bi952501g. Biochemistry. 1996. PMID: 8639594

7

FAP mutations destabilize transthyretin facilitating conformational changes required for amyloid formation.

Colon W, Lai Z, McCutchen SL, Miroy GJ, Strang C, Kelly JW. Colon W, et al. Among authors: kelly jw. Ciba Found Symp. 1996;199:228-38; discussion 239-42. doi: 10.1002/9780470514924.ch14. Ciba Found Symp. 1996. PMID: 8915613

8

Inhibiting transthyretin amyloid fibril formation via protein stabilization.

Miroy GJ, Lai Z, Lashuel HA, Peterson SA, Strang C, Kelly JW. Miroy GJ, et al. Among authors: kelly jw. Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15051-6. doi: 10.1073/pnas.93.26.15051. Proc Natl Acad Sci U S A. 1996. PMID: 8986762 Free PMC article.

9

Guanidine hydrochloride-induced denaturation and refolding of transthyretin exhibits a marked hysteresis: equilibria with high kinetic barriers.

Lai Z, McCulloch J, Lashuel HA, Kelly JW. Lai Z, et al. Among authors: kelly jw. Biochemistry. 1997 Aug 19;36(33):10230-9. doi: 10.1021/bi963195p. Biochemistry. 1997. PMID: 9254621

10

Transthyretin quaternary and tertiary structural changes facilitate misassembly into amyloid.

Kelly JW, Colon W, Lai Z, Lashuel HA, McCulloch J, McCutchen SL, Miroy GJ, Peterson SA. Kelly JW, et al. Adv Protein Chem. 1997;50:161-81. doi: 10.1016/s0065-3233(08)60321-6. Adv Protein Chem. 1997. PMID: 9338081 Review.

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