Lashuel HA - Search Results

1

Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation.

Lashuel HA, Lai Z, Kelly JW. Lashuel HA, et al. Biochemistry. 1998 Dec 22;37(51):17851-64. doi: 10.1021/bi981876+. Biochemistry. 1998. PMID: 9922152

2

Inhibiting transthyretin amyloid fibril formation via protein stabilization.

Miroy GJ, Lai Z, Lashuel HA, Peterson SA, Strang C, Kelly JW. Miroy GJ, et al. Among authors: lashuel ha. Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15051-6. doi: 10.1073/pnas.93.26.15051. Proc Natl Acad Sci U S A. 1996. PMID: 8986762 Free PMC article.

3

Guanidine hydrochloride-induced denaturation and refolding of transthyretin exhibits a marked hysteresis: equilibria with high kinetic barriers.

Lai Z, McCulloch J, Lashuel HA, Kelly JW. Lai Z, et al. Among authors: lashuel ha. Biochemistry. 1997 Aug 19;36(33):10230-9. doi: 10.1021/bi963195p. Biochemistry. 1997. PMID: 9254621

4

Transthyretin quaternary and tertiary structural changes facilitate misassembly into amyloid.

Kelly JW, Colon W, Lai Z, Lashuel HA, McCulloch J, McCutchen SL, Miroy GJ, Peterson SA. Kelly JW, et al. Among authors: lashuel ha. Adv Protein Chem. 1997;50:161-81. doi: 10.1016/s0065-3233(08)60321-6. Adv Protein Chem. 1997. PMID: 9338081 Review.

5

Recombinant human retinol-binding protein refolding, native disulfide formation, and characterization.

Xie Y, Lashuel HA, Miroy GJ, Dikler S, Kelly JW. Xie Y, et al. Among authors: lashuel ha. Protein Expr Purif. 1998 Oct;14(1):31-7. doi: 10.1006/prep.1998.0944. Protein Expr Purif. 1998. PMID: 9758748

6

Inhibiting transthyretin conformational changes that lead to amyloid fibril formation.

Peterson SA, Klabunde T, Lashuel HA, Purkey H, Sacchettini JC, Kelly JW. Peterson SA, et al. Among authors: lashuel ha. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):12956-60. doi: 10.1073/pnas.95.22.12956. Proc Natl Acad Sci U S A. 1998. PMID: 9789022 Free PMC article.

7

Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization.

Patricelli MP, Lashuel HA, Giang DK, Kelly JW, Cravatt BF. Patricelli MP, et al. Among authors: lashuel ha. Biochemistry. 1998 Oct 27;37(43):15177-87. doi: 10.1021/bi981733n. Biochemistry. 1998. PMID: 9790682

8

The nucleation of monomeric parallel beta-sheet-like structures and their self-assembly in aqueous solution.

Chitnumsub P, Fiori WR, Lashuel HA, Diaz H, Kelly JW. Chitnumsub P, et al. Among authors: lashuel ha. Bioorg Med Chem. 1999 Jan;7(1):39-59. doi: 10.1016/s0968-0896(98)00222-3. Bioorg Med Chem. 1999. PMID: 10199655

9

The most pathogenic transthyretin variant, L55P, forms amyloid fibrils under acidic conditions and protofilaments under physiological conditions.

Lashuel HA, Wurth C, Woo L, Kelly JW. Lashuel HA, et al. Biochemistry. 1999 Oct 12;38(41):13560-73. doi: 10.1021/bi991021c. Biochemistry. 1999. PMID: 10521263

10

A glimpse of a possible amyloidogenic intermediate of transthyretin.

Liu K, Cho HS, Lashuel HA, Kelly JW, Wemmer DE. Liu K, et al. Among authors: lashuel ha. Nat Struct Biol. 2000 Sep;7(9):754-7. doi: 10.1038/78980. Nat Struct Biol. 2000. PMID: 10966644

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